The CCR5Δ32 polymorphism is a 32-base pair deletion in the CCR5 gene that has been associated with slower HIV disease progression. However, its role in immune reconstitution during antiretroviral therapy (ART) remains unclear. We analyzed 236 virologically suppressed people living with HIV (PLHIV) after 24 months of ART, comprising 217 individuals homozygous for the wild-type CCR5 allele and 19 heterozygous carriers of CCR5Δ32...

Background Cutaneous leishmaniasis (CL) remains a neglected tropical disease that disproportionately affects indigenous populations, where transmission is shaped by complex socioenvironmental conditions. Our objective is to describe and analyze the sociodemographic, environmental, clinical, and therapeutic characteristics of CL cases in the Xakriabá indigenous population, and to explore associations between these characteristi...

Debris flows are among the most destructive natural processes in tropical mountainous regions, especially when they affect critical infrastructure. However, integrated methodologies that combine susceptibility analysis, numerical modeling, and structural vulnerability assessment remain scarce, particularly in humid tropical environments such as the Serra do Mar. This study proposes an integrated hazard assessment approach comb...

The search for safe and effective anaesthetic agents for aquaculture is essential to improve fish welfare and management practices. This study evaluated the anaesthetic efficacy of Origanum vulgare essential oil (OVEO) in juvenile tambaqui ( Colossoma macropomum ), an important Amazonian species. A total of 108 fish were exposed to immersion baths with increasing OVEO concentrations (19.04–57.12 mg L⁻ 1 ). Behavioral endpoints...

Understanding the mechanisms by which organisms adapt to environmental conditions is a fundamental question for ecology and evolution. In this study, we evaluate changes in gene expression of a marine mollusc, the eastern oyster Crassostrea virginica , associated with the physico‐chemical conditions and the levels of metals and other contaminants in their environment. The results indicate that transcript signatures can effecti...

Increasing utilization and human population density in the coastal zone is widely believed to place increasing stresses on the resident biota, but confirmation of this belief is somewhat lacking. While we have solid evidence that highly disturbed estuarine systems have dramatic changes in the resident biota (black and white if you will), we lack tools that distinguish the shades of grey. In part, this lack of ability to distin...