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Interpretable deep learning reveals spatiotemporal MRI features of brain aging that align with neurodegenerationNARA Subscribed
Cortical thinning and atrophy are hallmarks of brain aging that have been characterized using magnetic resonance imaging (MRI). Brain aging involves many neuroanatomic features whose effects on brain structure remain unexplored. To address this challenge, we trained interpretable deep neural networks (DNNs) to estimate brain age (BA) from T 1 -weighted ( T 1 w) MRI. By identifying MRI features unapparent to humans, DNNs can fi...
SNAPSHOT USA 2024: Year 6 of the Coordinated National Camera Trap Survey of the United StatesNARA Subscribed
Motivation SNAPSHOT USA is an annual, multi‐contributor camera trap survey of mammals across the United States. The growing SNAPSHOT USA dataset is intended for tracking the spatial and temporal responses of mammal populations to changes in land use, land cover and climate. These data will be useful for exploring the drivers of spatial and temporal changes in relative abundance and distribution, as well as the impacts of speci...
Aim The evolution of montane species provides critical insights into the drivers of adaptation and diversification. Topographic complexity, a defining feature of many mountainous landscapes, promotes ecological and geographic isolation, often accelerating speciation rates. However, the extent to which topographic complexity directly shapes diversification remains unresolved. Here, we investigate the evolutionary dynamics of An...
Alzheimer’s disease (AD) disproportionately affects women and carriers of the apolipoprotein E ε4 allele (APOE4), yet little is known about how sex and APOE interact to influence white matter (WM) integrity during disease progression. We integrated diffusion MRI and matched blood transcriptomic data to investigate these interactions and their underlying biological mechanisms. WM microstructure was quantified using diffusion te...
Offshore energy structures introduce hard substrate to soft substrate-dominant habitats and may act as artificial reefs providing shelter and food to aggregating fish. In the Northeast Atlantic, knowledge on these effects is limited to shallow habitats in the southern North Sea. Given that effects may be misinterpreted as ‘nature positive’ contributions, or underestimated and impacting ecosystem services like fisheries, this d...
Modeling Ringed and Bearded Seal Future Habitats Indicates Stability, Shifts, and RefugiaNARA Subscribed
Understanding how marine habitats are changing with a warming Arctic is essential for conservation, management, and adaptation strategies bearing tangible consequences for Arctic communities and ecosystems. Ringed seals and bearded seals rely on specific ice and snow conditions to support critical life history events affecting survival and reproduction. Here, we develop a panarctic habitat suitability model linking life events...
Marine megafauna species are affected by a wide range of anthropogenic threats. To evaluate the risk of such threats, species’ vulnerability to each threat must first be determined. We build on the existing threats classification scheme and ranking system of the International Union for Conservation of Nature (IUCN) Red List of Threatened Species by assessing the vulnerability of 256 marine megafauna species to 23 at‐sea threat...
The Toxicology Investigators Consortium 2024 Annual ReportNARA Subscribed
Bonefish Albula spp. in the Western Atlantic have historically been morphometrically and phenotypically indiscernible. We used biofluorescence in two sympatric, cryptic bonefish species, Albula goreensis and Albula vulpes , to develop a rapid and inexpensive in situ survey for species identification that can be used by managers and recreational anglers. Under ultraviolet (379–387 nm) and royal blue (440–457 nm) lights, the two...
The essential role of large research vessels in marine ecosystem observations and ocean sustainabilityNARA Subscribed
Our understanding of marine ecosystems and ability to manage them sustainably has come from multidisciplinary observations made repeatedly over long periods of time. These long‐term ecosystem observations depend on the capabilities of large research vessels, which play an essential role in the collection of global ocean observations. Research vessels serve as large, stable platforms for collecting high volume samples from the...
Understanding spatial dynamics and migratory behaviours of fish populations is essential for effective fisheries management. We focus on the migratory Atlantic tarpon ( Megalops atlanticus ) to explore how movement strategies and spatial life cycle patterns shape stock dynamics, contingent structure and mechanisms for collapse and recovery. The entrainment hypothesis posits that migratory routes are socially transmitted from e...
Validation of satellite-derived essential climate variable (ECV) datasets requires comparison against independent measurements. These independent measurements, which include ground-based, airborne, and other non-satellite-based measurements, are typically the product of a different measurement system and may include some contribution from models. These reference data therefore have their own characteristics, uncertainties, and...
A quality by design strategy for cocrystal design based on novel computational and experimental screening strategies: part ANARA Subscribed
While pharmaceutical Cocrystals have long been acknowledged as a promising method of enhancing a drugs bioavailability, they have not yet experienced widespread industrial adoption on the same scale as other multi-component drugs, such as salts and amorphous solid dispersions. This is partly due to the lack of a being no definitive screening strategy to identify suitable coformers, with the most cocrystal screening strategies...
Decoupling of temperature and growth of white spruce at western treeline, Alaska, is unrelated to intrinsic water stressNARA Subscribed
Late 20th century warming has weakened the relationship between temperature and growth in northern forests. This loss of sensitivity to temperature, often attributed to drought stress in warmer regions of the boreal forest, has also been observed in cool, mesic environments, where warming‐related growth declines are poorly understood. We used annually resolved ring‐width and carbon stable isotope (δ 13 C) chronologies from whi...