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Rationale Sex differences in the effects of cannabis have been demonstrated in animals, though the human evidence is more equivocal. In particular, more work is needed to better understand interactions between sex and dose in determining acute pharmacological effects of cannabis, especially at higher potencies of Δ 9 -tetrahydrocannabinol (THC). Objectives Sex differences were examined following a range of potencies of smoked...
Assessment of two minimally invasive methodologies for sex identification in the European eel, Anguilla anguillaNARA Subscribed
Sex is an important driver of variation in behaviour, ecology and physiology. Sex identification in the Critically Endangered European eel ( Anguilla anguilla ) currently requires fish sacrifice, or the use of morphological differences such as body length, which can be inaccurate in certain habitats and at intermediate body lengths. Non‐lethal tools for accurate sex identification in this species are therefore required. Here,...
Interpretable deep learning reveals spatiotemporal MRI features of brain aging that align with neurodegenerationNARA Subscribed
Cortical thinning and atrophy are hallmarks of brain aging that have been characterized using magnetic resonance imaging (MRI). Brain aging involves many neuroanatomic features whose effects on brain structure remain unexplored. To address this challenge, we trained interpretable deep neural networks (DNNs) to estimate brain age (BA) from T 1 -weighted ( T 1 w) MRI. By identifying MRI features unapparent to humans, DNNs can fi...
Alzheimer’s disease (AD) disproportionately affects women and carriers of the apolipoprotein E ε4 allele (APOE4), yet little is known about how sex and APOE interact to influence white matter (WM) integrity during disease progression. We integrated diffusion MRI and matched blood transcriptomic data to investigate these interactions and their underlying biological mechanisms. WM microstructure was quantified using diffusion te...
Improving eel pass efficiency: The role of crest shape and water flow in facilitating upstream juvenile eel migrationNARA Subscribed
River connectivity is crucial for the European eel ( Anguilla anguilla ) to complete its complex life cycle, which is vital for upstream recruitment to the declining population of this critically endangered catadromous fish. Eel passes, or ladders, are frequently installed on riverine structures, such as dams and weirs, to mitigate barrier effects and restore connectivity for upstream migrating eel. Efforts to optimise the eff...
Predicting the progression of MCI and Alzheimer’s disease on structural brain integrity and other features with machine learningNARA Subscribed
Machine learning (ML) on structural MRI data shows high potential for classifying Alzheimer’s disease (AD) progression, but the specific contribution of brain regions, demographics, and proteinopathy remains unclear. Using Alzheimer’s Disease Neuroimaging Initiative (ADNI) data, we applied an extreme gradient-boosting algorithm and SHAP (SHapley Additive exPlanations) values to classify cognitively normal (CN) older adults, th...
Sea trout, the anadromous ecotype of the species Salmo trutta , are subject to multiple threats, including exploitation and aquaculture impacts in the marine environment, habitat fragmentation and pollution in freshwaters, loss of genetic resilience due to interbreeding with hatchery strains and environmental change. Small streams contribute relatively little biomass to European sea trout stocks but are thought to be important...
Environmental influences on the phenology of immigrating juvenile eels over weirs at the tidal limit of regulated riversNARA Subscribed
Recruitment of the catadromous and critically endangered European eel Anguilla anguilla in Europe has declined substantially since the 1980s, with considerable knowledge gaps remaining in many aspects of their life cycle. The aim was to assess eel migration phenology in three regulated rivers in England between 2009 and 2019 through analyses of eel numbers using passes at their tidal limits, with calculation of the annual timi...
Additive manufacturing of patient specific bolus for radiotherapy: large scale production and quality assuranceNARA Subscribed
Bolus is commonly used to improve dose distributions in radiotherapy in particular if dose to skin must be optimised such as in breast or head and neck cancer. We are documenting four years of experience with 3D printed bolus at a large cancer centre. In addition to this we review the quality assurance (QA) program developed to support it. More than 2000 boluses were produced between Nov 2018 and Feb 2023 using fused depositio...
The European eel ( Anguilla anguilla L.) is a critically endangered catadromous fish. Their inshore and in-river arrival as glass eel and elvers is an important stage of their life cycle, marking the transition from marine to freshwater habitats. Considerable knowledge gaps remain on the temporal and spatial patterns of this transition period to freshwater residency. Stable isotope (SI) analysis (δ 13 C, δ 15 N) was used to as...
Optimising the design of passage facilities to restore fluvial connectivity for juvenile European eel (Anguilla anguilla) is a key priority within conservation efforts for the species, across the majority of its freshwater range. Employing an experimental setup that simulated gravity-fed upstream eel passes, this study demonstrated that novel V-profile passes, which incorporate two lateral slopes (15°), performed better than l...
Effects of preservation by ethanol on δ 13 C and δ 15 N of three tissues of the critically endangered European eel Anguilla anguillaNARA Subscribed
The temporal effects of ethanol preservation on the δ 13 C and δ 15 N values of tissues excised from European eel Anguilla anguilla were assessed. Preservation significantly enriched 13 C values of fin and mucus but not dorsal muscle. The 13 C enrichment occurred in the initial 15 days of preservation and was independent of initial eel mass. Tissue preservation effects on δ 15 N values were negligible. These tissue‐specific is...