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Floodplains are habitats with an outstanding biodiversity but have been strongly affected by anthropogenic activities such as channelization and bank enforcement. The remaining floodplains are impacted by climate change-driven alterations in the hydrological regime and by chemical stressors. However, the extent and interactive effects of these stressors are not well understood, especially in small-scale floodplains. In a mesoc...
Recommendations for Method Development and Validation of qPCR and dPCR Assays in Support of Cell and Gene Therapy Drug DevelopmentNARA Subscribed
The emerging use of qPCR and dPCR in regulated bioanalysis and absence of regulatory guidance on assay validations for these platforms has resulted in discussions on lack of harmonization on assay design and appropriate acceptance criteria for these assays. Both qPCR and dPCR are extensively used to answer bioanalytical questions for novel modalities such as cell and gene therapies. Following cross-industry conversations on th...
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