Background Chronic spontaneous urticaria (CSU) is a skin condition characterized by itchy hives and/or angioedema, impairing patients’ quality of life even with the current available medications. This study aims to evaluate the efficacy and safety of Ligelizumab, a high-affinity monoclonal anti-IgE antibody, in the treatment of CSU. Methods We performed a systematic review and meta-analysis in accordance with PRISMA criteria,...

This study aims to evaluate the efficacy and safety of ensifentrine in COPD patients. Following the PRISMA guidelines, we conducted a systematic review and meta-analysis, systematically searching PubMed, Web of Science, Scopus, and Cochrane library up to 12 December 2024, for randomized controlled trials (RCTs) evaluating ensifentrine compared to placebo in COPD patients. Eligibility criteria included studies reporting outcome...

Mangrove forests in the Arabian Gulf are under continuous threat. To increase plantations of gray mangrove ( Avicennia marina ) in the United Arab Emirates (UAE), 27 endophytic actinobacterial isolates obtained from mangrove roots were in vitro pre-screened to detect the polyamines (PAs) [putrescine (Put), spermidine (Spd), and spermine (Spm)]. We also determined the abilities of the endophytic PA-producing actinobacterial iso...