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Assessing shortnose sturgeon response to estuarine dredging in the Savannah River using a before-after control-impact (BACI) approachNARA Subscribed
Estuaries are productive ecosystems that support diverse aquatic species and human economies through fisheries, recreation, and navigation. However, coastal development and dredging have altered the ecological processes of estuarine habitats. In the Savannah River estuary, the Savannah Harbor Expansion Project (SHEP) deepened the river’s navigational channel by dredging to amplify vessel commerce. The endangered shortnose stur...
Earth's biodiversity is central to ecosystem health and resilience, providing essential functions and services. The Red Sea is a recognised marine biodiversity hotspot with high endemism and unique environmental conditions that support extensive but poorly resolved biodiversity. Here, we applied metagenomic analyses to sediment samples collected from coastal to deep‐sea environments during the Red Sea Decade Expedition 2022 to...
The Atlantic meridional overturning circulation (AMOC) is expected to decline dramatically over the 21st century, with severe impacts for Northern Hemisphere climate. After 20 years of sustained monitoring in the subtropics, a detectable AMOC weakening trend is now beginning to emerge. However, continuous observations at subpolar latitudes are currently too short-lived to determine any weakening signal above the large-amplitud...
The Rockall Trough, northwest of Scotland and Ireland, is a key conduit for the North Atlantic Current (NAC) and European Slope Current (ESC) transporting heat and salt toward the Nordic Seas and Arctic Ocean while mediating exchanges between the open ocean and the European shelf. We present a decade-long record of Rockall Trough circulation from the Ellett Array providing the first continuous estimates of heat and freshwater...
The Atlantic meridional overturning circulation (AMOC) has a notable seasonal component. This influences the jet stream and the location, frequency, and intensity of extreme weather events. Understanding this seasonality is important for mitigating the impacts of AMOC changes on European weather and climate. Here, we place meridional overturning and fluxes in a coherent framework. This framework highlights the integral relatio...
Voxel-wise insights into early Alzheimer’s disease pathology progression: the association with APOE and memory declineNARA Subscribed
Longitudinal investigation of the Apolipoprotein E (APOE) genotype’s impact on Alzheimer’s disease (AD) biomarker progression, focusing on amyloid beta (Aβ) accumulation and gray matter (GM) atrophy, integrating cognitive decline and baseline levels. Longitudinal florbetapir-PET and T1-weighted MRI data from 100 cognitively normal (CN) and mild cognitive impaired (MCI) participants both with considerable global Aβ accumulation...
Complementary value of molecular, phenotypic, and functional aging biomarkers in dementia predictionNARA Subscribed
DNA methylation age (MA), brain age (BA), and frailty index (FI) are putative aging biomarkers linked to dementia risk. We investigated their relationship and combined potential for prediction of cognitive impairment and future dementia risk using the ADNI database. Of several MA algorithms, DunedinPACE and GrimAge2, associated with memory, were combined in a composite MA alongside BA and a data-driven FI in predictive analyse...
The Atlantic Meridional Overturning Circulation (AMOC) transports heat and salt between the tropical Atlantic and Arctic oceans. The interior of the North Atlantic subpolar gyre (SPG) is responsible for the much of the water mass transformation in the AMOC, and the export of this water to intensified boundary currents is crucial for projecting air–sea interaction onto the strength of the AMOC. However, the magnitude and locati...
Observations of the eastern subpolar North Atlantic in the 2010s show exceptional freshening and cooling of the upper ocean, peaking in 2016 with the lowest salinities recorded for 120 years. Published theories for the mechanisms driving the freshening include: reduced transport of saltier, warmer surface waters northwards from the subtropics associated with reduced meridional overturning; shifts in the pathways of fresher, co...
Comprehensive analysis of epigenetic clocks reveals associations between disproportionate biological ageing and hippocampal volumeNARA Subscribed
The concept of age acceleration, the difference between biological age and chronological age, is of growing interest, particularly with respect to age-related disorders, such as Alzheimer’s Disease (AD). Whilst studies have reported associations with AD risk and related phenotypes, there remains a lack of consensus on these associations. Here we aimed to comprehensively investigate the relationship between five recognised meas...
Common, low-frequency, rare, and ultra-rare coding variants contribute to COVID-19 severityNARA Subscribed
The combined impact of common and rare exonic variants in COVID-19 host genetics is currently insufficiently understood. Here, common and rare variants from whole-exome sequencing data of about 4000 SARS-CoV-2-positive individuals were used to define an interpretable machine-learning model for predicting COVID-19 severity. First, variants were converted into separate sets of Boolean features, depending on the absence or the pr...
Designing conservation networks requires a well-structured framework for achieving essential objectives such as connectivity, replication or viability, and for considering local management and socioeconomic stakes. Although systematic conservation planning (SCP) approaches are increasingly used to inform such networks, their application remains challenging in large and poorly researched areas. This is especially the case in th...
Political and economic transitions have had substantial impacts on forest conservation. Where transitions are underway or anticipated, historical precedent and methods for systematically assessing future trends should be used to anticipate likely threats to forest conservation and design appropriate and prescient policy measures to counteract them. Myanmar is transitioning from an authoritarian, centralized state with a highly...
Heritable changes in regional cortical thickness with ageNARA Subscribed