Argininosuccinate lyase (ASL) is essential for the NO-dependent regulation of tyrosine hydroxylase (TH) and thus for catecholamine production. Using a conditional mouse model with loss of ASL in catecholamine neurons, we demonstrate that ASL is expressed in dopaminergic neurons in the substantia nigra pars compacta, including the ALDH1A1 + subpopulation that is pivotal for the pathogenesis of Parkinson disease (PD). Neuronal l...

Kelp are foundation species that support high levels of biodiversity and, either directly or indirectly provide a wide range of ecological goods and services to human society. In recent decades, due to the high demand for kelp-derived products such as alginate, commercial wild harvesting has increased, leading to declines of kelp biomass in some regions. Chile accounts for 40% of the global kelp harvest, with the subtidal kelp...