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The herbicide 2,4-dichlorophenoxyacetic acid (2,4-D) is widely used in agricultural systems, raising concerns about its potential genotoxic effects on non-target organisms. This cross-sectional observational field study evaluated nuclear abnormalities in exfoliated buccal mucosa cells from 36 grazing cattle maintained on a farm where 2,4-D was routinely used in Goiás, Brazil, and investigated their relationship with physiologi...
Chronic Alcohol Drinking Impairs Recognition Memory And Insulin-Associated Genes In The Medial Prefrontal CortexNARA Subscribed
Chronic alcohol drinking increases susceptibility to cognitive impairment; however, the underlying mechanisms remain unclear. In this study, we investigated the effects of chronic alcohol drinking on working and recognition memory in a Marchigian Sardinian alcohol-preferring (msP) rat line. Due to interest in insulin-based medications for alcohol use disorder, we examined insulin/insulin-like growth factor 1 (IGF-1) genes in t...
Purpose Catheter-based total renal denervation (TRDN) has recently gained FDA approval to lower blood pressure in patients with treatment-resistant hypertension. Current TRDN technologies indiscriminately destroy efferent (sympathetic) and afferent (sensory) renal nerves. However, preclinical studies suggest that the beneficial effects of TRDN may be due to ablation of afferent, rather than efferent, renal nerves. We developed...
Purpose We assessed the effectiveness and safety of cefiderocol in patients with Gram-negative bacterial infections, excluding Acinetobacter spp., in the early access programme (EAP) in Spain. Methods The retrospective, multicentre PERSEUS study (2018–2022) enrolled hospitalised patients with serious Gram-negative infections, except Acinetobacter spp., who received first-time cefiderocol for ≥ 72 h following requests through t...
Trait‐based approaches to study biodiversity responses to changing environmental conditions have become popular because these approaches provide context to how and why certain taxa shift in abundance within an assemblage. Trait‐based approaches also offer the potential to link shifts in assemblage composition to effects on ecosystem functions like rates of primary production, detrital decomposition, and nutrient uptake. Howeve...
Aim To examine the species richness, distribution and macroecological patterns of elasmobranch assemblages across a broad latitudinal gradient in the Eastern Pacific Ocean (EPO). Location The study area encompasses the Pacific coast of the American continent, spanning from 65°N to 60°S, and extending from the coastline to approximately 1000 km offshore, encompassing the oceanic archipelagos. Taxon Elasmobranchs. Methods Utilis...
Camera trap surveys of A tlantic F orest mammals: A data set for analyses considering imperfect detection (2004–2020)NARA Subscribed
Camera traps became the main observational method of a myriad of species over large areas. Data sets from camera traps can be used to describe the patterns and monitor the occupancy, abundance, and richness of wildlife, essential information for conservation in times of rapid climate and land‐cover changes. Habitat loss and poaching are responsible for historical population losses of mammals in the Atlantic Forest biodiversity...