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The Toxicology Investigators Consortium 2024 Annual ReportNARA Subscribed
Continental rifts and mantle convectionNARA Subscribed
In our study we investigated the hydrodynamic circulation of the Gulfs of Patras and Corinth through modelling. To this end, ROMS was used to numerically calculate the parameters of the waters for these peculiar semi-enclosed basins. Several oceanographic forcings were used with an emphasis on the tides and the winds. With several simulations, each focusing on a specific element, we were able to describe more accurately the dy...
In this work we present a super-resolution approach for deriving high-spatial-resolution and high-temporal-resolution ocean colour satellite datasets. The technique is based on DINEOF (data-interpolating empirical orthogonal functions), a data-driven method that uses the spatio-temporal coherence of analysed datasets to infer missing information. DINEOF is used here to effectively increase the spatial resolution of satellite d...
Satellite observations provide a global or near-global coverage of the World Ocean. They are however affected by clouds (among others), which severely reduce their spatial coverage. Different methods have been proposed in the literature to reconstruct missing data in satellite observations. For many applications of satellite observations, it has been increasingly important to accurately reflect the underlying uncertainty of th...
The Toxicology Investigators Consortium 2023 Annual ReportNARA Subscribed
Hypervirulent ribotypes (HVRTs) of Clostridioides difficile such as ribotype (RT) 027 are epidemiologically important. This study evaluated whether MALDI-TOF can distinguish between strains of HVRTs and non-HVRTs commonly found in Europe. Obtained spectra of clinical C. difficile isolates (training set, 157 isolates) covering epidemiologically relevant HVRTs and non-HVRTs found in Europe were used as an input for different mac...
The Toxicology Investigators Consortium 2022 Annual ReportNARA Subscribed
Acid sphingomyelinase expression is associated with survival in resectable pancreatic ductal adenocarcinomaNARA Subscribed
Pancreatic adenocarcinoma (PDAC) is one of the most common cancers worldwide. Unfortunately, the prognosis of PDAC is rather poor, and for instance, in the USA, over 47,000 people die because of pancreatic cancer annually. Here, we demonstrate that high expression of acid sphingomyelinase in PDAC strongly correlates with long-term survival of patients, as revealed by the analysis of two independent data sources. The positive e...
NEOTROPICAL FRESHWATER FISHES : A dataset of occurrence and abundance of freshwater fishes in the NeotropicsNARA Subscribed
The Neotropical region hosts 4225 freshwater fish species, ranking first among the world's most diverse regions for freshwater fishes. Our NEOTROPICAL FRESHWATER FISHES data set is the first to produce a large‐scale Neotropical freshwater fish inventory, covering the entire Neotropical region from Mexico and the Caribbean in the north to the southern limits in Argentina, Paraguay, Chile, and Uruguay. We compiled 185,787 distri...
Pancreas ductal adenocarcinoma (PDAC) remains a malignant tumor with very poor prognosis and low 5-year overall survival. Here, we aimed to simultaneously target mitochondria and lysosomes as a new treatment paradigm of malignant pancreas cancer in vitro and in vivo. We demonstrate that the clinically used sphingosine analog FTY-720 together with PAPTP, an inhibitor of mitochondrial Kv1.3, induce death of pancreas cancer cells...
Major depressive disorder (MDD) is a very common, severe disease with a lifetime prevalence of ~ 10%. The pathogenesis of MDD is unknown and, unfortunately, therapy is often insufficient. We have previously reported that ceramide levels are increased in the blood plasma of patients with MDD and in mice with experimental MDD. Here, we demonstrate that ceramide-enriched exosomes in the blood plasma are increased in mice with str...
Ants, an ecologically successful and numerically dominant group of animals, play key ecological roles as soil engineers, predators, nutrient recyclers, and regulators of plant growth and reproduction in most terrestrial ecosystems. Further, ants are widely used as bioindicators of the ecological impact of land use. We gathered information of ant species in the Atlantic Forest of South America. The ATLANTIC ANTS data set, which...