Impaired T-cell responses to mitogens and high T-cell activation marker (TAM) expression on Mycobacterium tuberculosis –specific T-cells characterize immunopathology in patients with tuberculosis (TB). In a study of patients with TB ( n = 60) and asymptomatic contacts (controls, n = 37), we found that TB patients had higher CD38 + T-cell proportions specific for M. tuberculosis protein (PPD Mtb ), yet total proportions of PPD...