Alexander Gerhard results 61
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Peripheral microRNA signature in genetic frontotemporal dementia—findings from the GENFI initiativeNARA Subscribed
Frontotemporal dementia (FTD) is a neurodegenerative disease characterized by significant clinical and genetic heterogeneity, with approximately 40% of cases linked to hereditary genetic mutations, including MAPT , GRN , and C9ORF72 . Recently, microRNAs (miRNAs) have emerged as key regulators of cellular processes related to neurodegeneration and as potential biomarkers for FTD. However, their relevance in presymptomatic stag...
Migratory Birds Advance Spring Arrival and Egg‐Laying in the Arctic, Mostly by Travelling FasterNARA Subscribed
In the current warming climate, many organisms in seasonal environments advance their timing of reproduction to benefit from resource peaks earlier in spring. For migrants, the potential to advance reproduction may be constrained by their migration strategies, notably their ability to advance arrival at the breeding grounds. Recent studies show various changes in migration strategies, including wintering closer to the breeding...
Aim Endemic species, characterised by limited geographic ranges, face a high risk of extinction. The neotropical region harbours diverse ecosystems and a substantial number of endemic species, thus identifying areas of high endemism is crucial for protecting unique and threatened species and ecosystems. Vascular epiphytes—nonparasitic plants that grow on other plants without contact with the soil—exhibit remarkable diversity i...
Long-term impact of basin-wide wastewater management on faecal pollution levels along the entire Danube RiverNARA Subscribed
The Danube River is, at 2857 km, the second longest river in Europe and the most international river in the world with 19 countries in its catchment. Along the entire river, faecal pollution levels are mainly influenced by point-source emissions from treated and untreated sewage of municipal origin under base-flow conditions. In the past 2 decades, large investments in wastewater collection and treatment infrastructure were ma...
Conservation status of vascular epiphytes in the neotropicsNARA Subscribed
The economic use of deep geothermal energy is fundamentally controlled by the factors of rock permeability, temperature gradient, and depth. The carbonates of the Northern Limestone Alps are considered possible hydrothermal deep aquifers in Tyrol. This is the so-called main dolomite and Wetterstein limestone. For an initial assessment of the geothermal potential, information from the deep Kramsach Th1 borehole was used. With a...
NEOTROPICAL FRESHWATER FISHES : A dataset of occurrence and abundance of freshwater fishes in the NeotropicsNARA Subscribed
The Neotropical region hosts 4225 freshwater fish species, ranking first among the world's most diverse regions for freshwater fishes. Our NEOTROPICAL FRESHWATER FISHES data set is the first to produce a large‐scale Neotropical freshwater fish inventory, covering the entire Neotropical region from Mexico and the Caribbean in the north to the southern limits in Argentina, Paraguay, Chile, and Uruguay. We compiled 185,787 distri...
Bergbaukunde, quo vadis?NARA Subscribed
Zusammenfassung Um dem Klimawandel und dem zunehmenden Wettbewerb beim Zugang zu Ressourcen zu begegnen, hat die Europäische Union im sogenannten Green Deal weitreichende Transformationen in den Bereichen Energie und Digitalisierung sowie die Umstellung des Wirtschaftssystems hin zu einer inklusiven Kreislaufwirtschaft festgelegt. Aus Sicht des Bergbaus bedeuten diese Transformationen einen weiterhin wachsenden Rohstoffbedarf,...
Is the oxidative potential of components of fine particulate matter surface-mediated?NARA Subscribed
Redox-active substances in fine particulate matter (PM) contribute to inhalation health risks through their potential to generate reactive oxygen species in epithelial lung lining fluid (ELF). The ELF’s air–liquid interface (ALI) can play an important role in the phase transfer and multi-phase reactions of redox-active PM constituents. We investigated the influence of interfacial processes and properties by scrubbing of coated...
Opinion on acetaldehyde as a flavouring substance: considerations for risk assessment Acetaldehyde occurs naturally in many foods and is also used as a flavouring due to its fruity aroma. The International Agency for Research on Cancer (IARC) classified acetaldehyde as possibly carcinogenic to humans and, in combination with oral intake via alcoholic beverages, as carcinogenic to humans. Therefore, the question arises whether...
The compositions of hydrothermal fluids in back-arc basins (BABs) can be affected by the influx of magmatic fluids into systems that are dominated by reactions between basement rocks and seawater-derived fluids. The East Scotia Ridge (ESR) in the Scotia Sea hosts such hydrothermal systems where the role of magmatic fluid influx has not yet been addressed. During expedition PS119 in 2019, three chimneys were sampled from the E2...
With increasing frequency and intensity of climate change events, it is crucial to understand how different components of temperature fluctuations affect the thermal tolerance and performance of marine primary producers. We used a controlled indoor-mesocosm set-up to test the effect of a temperature fluctuation frequency gradient on a natural phytoplankton community. Within a frequency gradient, we allowed the temperature to f...
sPlotOpen – An environmentally balanced, open‐access, global dataset of vegetation plotsNARA Subscribed
Motivation Assessing biodiversity status and trends in plant communities is critical for understanding, quantifying and predicting the effects of global change on ecosystems. Vegetation plots record the occurrence or abundance of all plant species co‐occurring within delimited local areas. This allows species absences to be inferred, information seldom provided by existing global plant datasets. Although many vegetation plots...
Features and applications of a field imaging chlorophyll fluorometer to measure stress in agricultural plantsNARA Subscribed
Most non-destructive methods for plant stress detection do not measure the primary stress response but reactions of processes downstream of primary events. For instance, the chlorophyll fluorescence ratio F v /F m , which indicates the maximum quantum yield of photosystem II, can be employed to monitor stress originating elsewhere in the plant cell. This article describes the properties of a sensor to quantify herbicide and pa...
The coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread worldwide. Bacterial co-infections are associated with unfavourable outcomes in respiratory viral infections; however, microbiological and antibiotic data related to COVID-19 are sparse. Adequate use of antibiotics in line with antibiotic stewardship (ABS) principles is warranted during the pandemic. We...
Aristotle’s lobster: the image in the textNARA Subscribed
The Anatomai , a lost work written by Aristotle, must have contained a collection of various drawings and figures of species as well as their organs. In his texts (mainly the Historia animalium ), Aristotle is often referring to the drawings after the description of species. Our study applies the method of the comparative view (‘Vergleichendes Sehen’) to provide an access to and reconstruction of Aristotle’s lost illustrations...