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An endogenous human peptide derived from α1-antitrypsin as a novel pharmacological inhibitor of Bordetella pertussis toxinNARA Subscribed
Pertussis, also known as whooping cough, is a highly infectious respiratory disease caused by the bacterium Bordetella pertussis . The bacterial virulence factor, pertussis toxin (PT), is associated with the manifestation of the characteristic symptoms of pertussis and the severe form of this disease. Increasing case numbers and the lack of treatment options highlight the need to develop novel pharmacological strategies, e.g.,...
Epidote group minerals, including allanite, clinozoisite and epidote are common in a range of metamorphic, igneous and hydrothermal systems, and are stable across a wide range of pressure – temperature ( P–T ) conditions. These minerals can incorporate substantial amounts of rare earth elements (REEs) during their crystallisation, making them potential candidates for Lu–Hf geochronology to provide age constraints on various ge...
Clinical chatbots are increasingly used to help integrate genetic testing into clinical contexts, but no chatbot exists for A polipoprotein L1 ( APOL1 ) genetic testing of living kidney donor (LKD) candidates of African ancestry. Our study aimed to culturally adapt and assess perceptions of the Gia® chatbot to help integrate APOL1 testing into LKD evaluation. Ten focus groups and post-focus group surveys were conducted with 54...
Common, low-frequency, rare, and ultra-rare coding variants contribute to COVID-19 severityNARA Subscribed
The combined impact of common and rare exonic variants in COVID-19 host genetics is currently insufficiently understood. Here, common and rare variants from whole-exome sequencing data of about 4000 SARS-CoV-2-positive individuals were used to define an interpretable machine-learning model for predicting COVID-19 severity. First, variants were converted into separate sets of Boolean features, depending on the absence or the pr...
In this paper, we outline the need for a coordinated international effort toward the building of an open-access Global Ocean Oxygen Database and ATlas (GO 2 DAT) complying with the FAIR principles (Findable, Accessible, Interoperable, and Reusable). GO 2 DAT will combine data from the coastal and open ocean, as measured by the chemical Winkler titration method or by sensors (e.g., optodes, electrodes) from Eulerian and Lagrang...
Runs of homozygosity in killer whale genomes provide a global record of demographic historiesNARA Subscribed
Runs of homozygosity (ROH) occur when offspring inherit haplotypes that are identical by descent from each parent. Length distributions of ROH are informative about population history; specifically, the probability of inbreeding mediated by mating system and/or population demography. Here, we investigated whether variation in killer whale ( Orcinus orca ) demographic history is reflected in genome‐wide heterozygosity and ROH l...
Host-specific and tissue-dependent orchestration of microbiome community structure in traditional rice paddy ecosystemsNARA Subscribed
Background and aim Rice and duckweed are two monocotyledonous plants that naturally coexist in paddy fields. While the presence of duckweed in paddy fields significantly improves rice productivity, the interplay between soil microbes and the two plant hosts in this agroecosystem remains unexplored. Methods We compared the bacterial community structure between duckweed, rice and soil from multiple rice paddies. We also isolated...
Comparative genome analysis of P seudomonas knackmussii B 13, the first bacterium known to degrade chloroaromatic compoundsNARA Subscribed
Summary P seudomonas knackmussii B 13 was the first strain to be isolated in 1974 that could degrade chlorinated aromatic hydrocarbons. This discovery was the prologue for subsequent characterization of numerous bacterial metabolic pathways, for genetic and biochemical studies, and which spurred ideas for pollutant bioremediation. In this study, we determined the complete genome sequence of B 13 using next generation sequencin...