Frontotemporal dementia (FTD) is a neurodegenerative disease characterized by significant clinical and genetic heterogeneity, with approximately 40% of cases linked to hereditary genetic mutations, including MAPT , GRN , and C9ORF72 . Recently, microRNAs (miRNAs) have emerged as key regulators of cellular processes related to neurodegeneration and as potential biomarkers for FTD. However, their relevance in presymptomatic stag...

This study combines the method of climate analogue regions with a bioclimatic approach. Bioclimate analogue regions were determined for the Rhenish lignite mining area in western Germany, which will face a major structural change in the following decades. These analogue regions currently experience a similar number of days with heat stress compared to the projected future (RCP8.5) at the end of the century in the investigation...

Density-driven flow caused by concomitant differences in temperature and salinity, known as thermohaline convection, is important in understanding the circulation of deep geofluids, e.g., in geothermal energy production. We carried out experiments of free thermal and thermohaline convection in homogeneous isotropic media using a laboratory-scale two-dimensional tank filled with glass beads representing a porous medium. Glass b...

Machine learning has grown in popularity in the past few years for susceptibility and hazard mapping tasks. Necessary steps for the generation of a susceptibility or hazard map are repeatedly implemented in new studies. We present a Random Forest classifier-based landslide susceptibility and hazard mapping framework to facilitate future mapping studies using machine learning. The framework, as a piece of software, follows the...

Since late 2021, the variant landscape of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been dominated by the variant of concern (VoC) Omicron and its sublineages. We and others have shown that the detection of Omicron-BA.1 and -BA.2-positive respiratory specimens by rapid antigen tests (RATs) is impaired compared to Delta VoC-containing samples. Here, in a single-center retrospective laboratory study, w...

Diagnostic tests for direct pathogen detection have been instrumental to contain the severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) pandemic. Automated, quantitative, laboratory-based nucleocapsid antigen (Ag) tests for SARS-CoV-2 have been launched alongside nucleic acid-based test systems and point-of-care (POC) lateral-flow Ag tests. Here, we evaluated four commercial Ag tests on automated platforms for t...

In this study, we describe a methodology to derive climate analogue cities for spatially highly resolved future climate scenarios. For the computation, a reduced and in hindsight bias-adjusted EURO-CORDEX EUR-11 dataset is used based on two climate scenarios (RCP4.5 and RCP8.5). A total of 389 European cities are processed by the algorithm, which uses five statistical climate variables (2-m air temperature average and amplitud...

During 2022, the COVID-19 pandemic has been dominated by the variant of concern (VoC) Omicron (B.1.1.529) and its rapidly emerging subvariants, including Omicron-BA.1 and -BA.2. Rapid antigen tests (RATs) are part of national testing strategies to identify SARS-CoV-2 infections on site in a community setting or to support layman’s diagnostics at home. We and others have recently demonstrated an impaired RAT detection of infect...

Flux measurements over heterogeneous surfaces with growing vegetation and a limited fetch are a difficult task, as measurement heights that are too high or too low above the canopy adversely affect results. The aim of this study is to assess implications from measurement height in regard to low-pass filtering, footprint representativeness, and energy balance closure for a clear-cut site with regrowing vegetation of varying hei...

Since autumn 2020, rapid antigen tests (RATs) have been implemented in several countries as an important pillar of the national testing strategy to rapidly screen for infections on site during the SARS-CoV-2 pandemic. The current surge in infection rates around the globe is driven by the variant of concern (VoC) omicron (B.1.1.529). Here, we evaluated the performance of nine SARS-CoV-2 RATs in a single-centre laboratory study....

On November 26, 2021, the World Health Organization classified B.1.1.529 as a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant of concern (VoC), named omicron. Spike -gene dropouts in conventional SARS-CoV-2 PCR systems have been reported over the last weeks as indirect diagnostic evidence for the identification of omicron. Here, we report the combination of PCRs specific for heavily mutated sites in the sp...

A versatile portfolio of diagnostic tests is essential for the containment of the severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) pandemic. Besides nucleic acid-based test systems and point-of-care (POCT) antigen (Ag) tests, quantitative, laboratory-based nucleocapsid Ag tests for SARS-CoV-2 have recently been launched. Here, we evaluated four commercial Ag tests on automated platforms and one POCT to detect...

To predict species responses to anthropogenic disturbances and climate change, it is reasonable to use species with high sensitivity to such factors. Snow sheep ( Ovis nivicola ) could represent a good candidate for this; as the only large herbivore species adapted to the cold and alpine habitats of northeastern Siberia, it plays a crucial role in its ecosystem. Despite having an extensive geographical distribution among all o...