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The myofibrillar myopathy–linked variant DES-p.T341P impairs desmin filament assemblyNARA Subscribed
Background Desminopathies are clinical heterogenous and range from isolated skeletal myopathies to different cardiomyopathies or combinations of both. At the molecular level, an aberrant cytoplasmic desmin aggregation is a typical hallmark of pathogenic DES variants. Currently, it is difficult to predict an aberrant desmin aggregation of novel DES variants without functional analysis. Methods Therefore, we investigate in this...
Diagnosis of brain metastases (BM) has traditionally marked a turning point in treatment goals and prognosis of patients with breast cancer (BC). However, new systemic treatment options have both prevented the development and improved the prognosis of BC patients with BM. Stereotactic radiotherapy techniques (SRT) have widely replaced whole brain radiotherapy (WBRT) in patients with limited BM, yielding impressive survival at...
The abscopal effect in metastatic lung cancer: a retrospective analysis of combined radiotherapy and immunotherapyNARA Subscribed
Background The abscopal effect (AbE) refers to the regression of non-irradiated tumors following localized radiotherapy (RT), suggesting a systemic immune-mediated response. The combination of RT with immunotherapy (IO) has been proposed to enhance the AbE by overcoming RT-induced immunosuppressive mechanisms, but robust evidence, specifically in non-small cell lung cancer (NSCLC), is lacking. This study aimed to determine the...
Motivation Here, we make available a second version of the BioTIME database, which compiles records of abundance estimates for species in sample events of ecological assemblages through time. The updated version expands version 1.0 of the database by doubling the number of studies and includes substantial additional curation to the taxonomic accuracy of the records, as well as the metadata. Moreover, we now provide an R packag...
Fatal dengue virus infection in an unvaccinated travelerNARA Subscribed
Dengue is an increasing threat to individuals living in or visiting endemic countries. Effective vaccines have become available, but their use in travelers is typically only recommended to individuals with documented prior infection. We present a fatal case of severe dengue in an unvaccinated traveler without known prior dengue virus infection but longitudinal serologic and molecular evidence for secondary infection. In the co...
The impact of leg position on muscle blood flow and oxygenation during low-intensity rhythmic plantarflexion exerciseNARA Subscribed
Purpose Resistance training (RT) is an effective countermeasure to combat physical deconditioning whereby localized hypoxia within the limb increases metabolic stress eliciting muscle adaptation. The current study sought to examine the influence of gravity on muscle oxygenation (SmO 2 ) alongside vascular hemodynamic responses. Methods In twelve young healthy adults, an ischemic occlusion test and seven minutes of low-intensit...
Combination strategy for consistent final, rapid and predicted Earth rotation parametersNARA Subscribed
The accurate knowledge of the Earth’s orientation and rotation in space is essential for a broad variety of scientific and societal applications. Among others, these include global positioning, near-Earth and deep-space navigation, the realisation of precise reference and time systems as well as studies of geodynamics and global change phenomena. In this paper, we present a refined strategy for processing and combining Very Lo...
TRY plant trait database – enhanced coverage and open accessNARA Subscribed
Plant traits—the morphological, anatomical, physiological, biochemical and phenological characteristics of plants—determine how plants respond to environmental factors, affect other trophic levels, and influence ecosystem properties and their benefits and detriments to people. Plant trait data thus represent the basis for a vast area of research spanning from evolutionary biology, community and functional ecology, to biodivers...
Aim We compared the power of different nuclear markers to investigate genetic structure of southern Balkan wild boar. We distinguished between historic events, such as isolation in different refugia during glacial periods, from recent demographic processes, such as naturally occurring expansions. Location Southern Balkans/Greece. Methods We sampled 555 wild boars from 20 different locations in southern Balkans/Greece. All indi...
Summary V ariovorax paradoxus B 4 is able to utilize 2‐mercaptosuccinate ( MS ) as sole carbon, sulfur and energy source. The whole genome of V . paradoxus B 4 was sequenced, annotated and evaluated with special focus on genomic elements related to MS metabolism. The genome encodes two chromosomes harbouring 5 795 261 and 1 353 255 bp . A total of 6753 putative protein‐coding sequences were identified. Based on the genome and...