Alexander Hoffmann results 29
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The role of ciliary function in airway epithelial defense against Pseudomonas aeruginosaNARA Subscribed
Respiratory cilia play a crucial role in clearing pathogens from the airway, and understanding how Pseudomonas aeruginosa (PA) impairs their function is essential for developing targeted therapies to enhance airway epithelial defense and hamper bacterial invasion. Thus, we investigated the mechanisms by which PA impairs respiratory cilia function and identified pharmacological interventions to restore cilia motility. We used m...
Tracking reduction-induced molecular changes in pathological free light chains by SV-AUCNARA Subscribed
Multiple myeloma is a blood cancer characterized by plasma cell proliferation and excessive production of monoclonal proteins, often leading to renal complications and other forms of organ damage. A set of nine immunoglobulin free light chain (FLC) samples purified from urine of multiple myeloma patients was subjected to sedimentation velocity analysis. Aim of the study was to track changes of the oligomerization state of each...
Despite being central to the implementation of conservation policies, the usefulness of the International Union for Conservation of Nature (IUCN) Red List of Threatened Species is hampered by the 14% of species classified as data‐deficient (DD) because information to evaluate these species’ extinction risk was lacking when they were last assessed or because assessors did not appropriately account for uncertainty. Robust method...
Comparison of Extraction Methods for the Detection of Tick-Borne Encephalitis Virus RNA in Goat Raw Milk and Cream CheeseNARA Subscribed
Infection with the tick-borne encephalitis virus (TBEV) can cause meningitis, meningoencephalitis and myelitis in humans. TBEV is an enveloped RNA virus of the family Flaviviridae , which is mostly transmitted via tick bites. However, transmission by consumption of virus-contaminated goat raw milk and goat raw milk products has also been described. Only a few methods have been reported for the detection of TBEV in food so far....
Multi-year, post-harvesting impact assessment in a neotropical secondary Atlantic ForestNARA Subscribed
Subject to overexploitation in the past centuries, the Atlantic Forest is subject to very rigorous protection rules. However, the law is a controversial issue since landowners are not compensated for the limited choice of land use possibilities. We believe that, alternatively to a general timber harvest ban, sustainable forest management of the Atlantic Forest has the potential to generate income for the landowners while susta...
ASL expression in ALDH1A1+ neurons in the substantia nigra metabolically contributes to neurodegenerative phenotypeNARA Subscribed
Argininosuccinate lyase (ASL) is essential for the NO-dependent regulation of tyrosine hydroxylase (TH) and thus for catecholamine production. Using a conditional mouse model with loss of ASL in catecholamine neurons, we demonstrate that ASL is expressed in dopaminergic neurons in the substantia nigra pars compacta, including the ALDH1A1 + subpopulation that is pivotal for the pathogenesis of Parkinson disease (PD). Neuronal l...
Room temperature stable multitalent: highly reactive and versatile copper guanidine complexes in oxygenation reactionsNARA Subscribed
Inspired by the efficiency of natural enzymes in organic transformation reactions, the development of synthetic catalysts for oxygenation and oxidation reactions under mild conditions still remains challenging. Tyrosinases serve as archetype when it comes to hydroxylation reactions involving molecular oxygen. We herein present new copper(I) guanidine halide complexes, capable of the activation of molecular oxygen at room tempe...
Impact of high salinity and the compatible solute glycine betaine on gene expression of Bacillus subtilisNARA Subscribed
Summary The Gram‐positive bacterium Bacillus subtilis is frequently exposed to hyperosmotic conditions. In addition to the induction of genes involved in the accumulation of compatible solutes, high salinity exerts widespread effects on B. subtilis physiology, including changes in cell wall metabolism, induction of an iron limitation response, reduced motility and suppression of sporulation. We performed a combined whole‐trans...
Tropical rainforest flies carrying pathogens form stable associations with social nonhuman primatesNARA Subscribed
Living in groups provides benefits but also incurs costs such as attracting disease vectors. For example, synanthropic flies associate with human settlements, and higher fly densities increase pathogen transmission. We investigated whether such associations also exist in highly mobile nonhuman primate (NHP) Groups. We studied flies in a group of wild sooty mangabeys ( Cercocebus atys atys ) and three communities of wild chimpa...