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Complex relative sea‐level (RSL) changes are associated with the deglaciation of the British and Irish Ice Sheet (BIIS). Sediment archives from Loch Bad na h‐Achlaise, an isolation basin in NW Scotland, UK, span Late Glacial to Holocene time and record sea‐level change and ice proximity via a geochemical and biostratigraphic multiproxy approach. Osmium and carbon isotope, carbon and nitrogen content, and X‐ray fluorescence (XR...
Raised shorelines provide important constraints on past sea levels, glacial isostatic adjustment (GIA), and rates and directions of vertical crustal motion. Although most raised shorelines across NW Scotland relate to post‐Last Glacial Maximum (LGM) glacial‐isostatic rebound, many undated shorelines lie above the marine limit established from isolation basins. Here, we present new optically stimulated luminescence (OSL) ages f...
Circulating cell-free DNA in health and disease — the relationship to health behaviours, ageing phenotypes and metabolomicsNARA Subscribed
Circulating cell-free DNA (cf-DNA) has emerged as a promising biomarker of ageing, tissue damage and cellular stress. However, less is known about health behaviours, ageing phenotypes and metabolic processes that lead to elevated cf-DNA levels. We sought to analyse the relationship of circulating cf-DNA level to age, sex, smoking, physical activity, vegetable consumption, ageing phenotypes (physical functioning, the number of...
Common, low-frequency, rare, and ultra-rare coding variants contribute to COVID-19 severityNARA Subscribed
The combined impact of common and rare exonic variants in COVID-19 host genetics is currently insufficiently understood. Here, common and rare variants from whole-exome sequencing data of about 4000 SARS-CoV-2-positive individuals were used to define an interpretable machine-learning model for predicting COVID-19 severity. First, variants were converted into separate sets of Boolean features, depending on the absence or the pr...
Local and regional constraints on relative sea‐level changes in southern Isle of Skye, Scotland, since the Last Glacial MaximumNARA Subscribed
New relative sea‐level (RSL) data constrain the timing and magnitude of RSL changes in the southern Isle of Skye following the Last Glacial Maximum (LGM). We identify a marine limit at ~ 23 m OD, indicating RSL ~20 m above present c . 15.1 ka. Isolation basin data, supported by terrestrial and marine limiting dates, record an RSL fall to 11.59 m above present by c . 14.2 ka. This RSL fall occurs across the time of global Meltw...
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