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Springer Nature1
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Pharmaceutical Research1
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20211
Alexander Solms results 1 · Newest (Page 1/1, per page 25)
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Which Analysis Approach Is Adequate to Leverage Clinical Microdialysis Data? A Quantitative Comparison to Investigate Exposure and Response Exemplified by LevofloxacinNARA Subscribed
Pharmaceutical Research · 2021 · Vol. 38 · Issue 3 · Springer
David Busse; André Schaeftlein; Alexander Solms; Luis Ilia; Robin Michelet; Markus Zeitlinger; Wilhelm Huisinga; Charlotte Kloft
Purpose Systematic comparison of analysis methods of clinical microdialysis data for impact on target-site drug exposure and response. Methods 39 individuals received a 500 mg levofloxacin short-term infusion followed by 24-h dense sampling in plasma and microdialysate collection in interstitial space fluid (ISF). ISF concentrations were leveraged using non-compartmental (NCA) and compartmental analysis (CA) via (ii) relative...
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