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International Archives of Occupational and Environmental Health · 2026 · Vol. 99 · Issue 2 · Springer
European Journal of Clinical Pharmacology · 2021 · Vol. 77 · Issue 10 · Springer
Purpose AT04A and AT06A are two AFFITOPE® peptide vaccine candidates being developed for the treatment of hypercholesterolemia by inducing proprotein convertase subtilisin/kexin type 9 (PCSK9)-specific antibodies. This study aimed to investigate safety, tolerability, antibody development, and reduction of low-density lipoprotein cholesterol (LDLc) following four subcutaneous immunizations. Methods This phase I, single-blind, r...