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NARA Subscribed1
Publisher
Springer Nature1
Journal
Pflügers Archiv - European Journal of Physiology1
Publication Year
20201
Alexandra Pinggera results 1 · Newest (Page 1/1, per page 25)
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RBP2 stabilizes slow Cav1.3 Ca2+ channel inactivation properties of cochlear inner hair cellsNARA Subscribed
Pflügers Archiv - European Journal of Physiology · 2020 · Vol. 472 · Issue 1 · Springer
Nadine J. Ortner; Alexandra Pinggera; Nadja T. Hofer; Anita Siller; Niels Brandt; Andrea Raffeiner; Kristina Vilusic; Isabelle Lang; Kerstin Blum; Gerald J. Obermair; Eduard Stefan; Jutta Engel; Jörg Striessnig
Cav1.3 L-type Ca 2+ channels (LTCCs) in cochlear inner hair cells (IHCs) are essential for hearing as they convert sound-induced graded receptor potentials into tonic postsynaptic glutamate release. To enable fast and indefatigable presynaptic Ca 2+ signaling, IHC Cav1.3 channels exhibit a negative activation voltage range and uniquely slow inactivation kinetics. Interaction with CaM-like Ca 2+ -binding proteins inhibits Ca 2+...
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