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Marine megafauna species are affected by a wide range of anthropogenic threats. To evaluate the risk of such threats, species’ vulnerability to each threat must first be determined. We build on the existing threats classification scheme and ranking system of the International Union for Conservation of Nature (IUCN) Red List of Threatened Species by assessing the vulnerability of 256 marine megafauna species to 23 at‐sea threat...
The Toxicology Investigators Consortium 2024 Annual ReportNARA Subscribed
For the first time, this study reports the content of tropane alkaloids (TAs) in soybean and soymeal samples sourced from 13 different countries, as well as in various cereals (including corn, millet, wheat, and sorghum) and a product (Super Cereals). The analysis was conducted using a fully validated solid-liquid extraction (SLE) with dilute-and-shoot (DnS) method along with a liquid chromatography-tandem mass spectrometry (L...
An engineered PD1-Fc fusion produced in N. benthamiana plants efficiently blocks PD1/PDL1 interactionNARA Subscribed
Key message Plant-made PD1–Fc fusions engineered for optimized glycosylation and Fc-receptor engagement are highly efficient in blocking PD1/PDL1 interactions and can be cost-effective alternatives to antibody-based immune checkpoint inhibitors. Abstract Immune checkpoint inhibitors (ICIs) are antibodies to receptors that have pivotal roles during T-cell activation processes. The programmed cell death 1 (PD1) can be regarded a...
One of the leading challenges in Water Resource Recovery Facility monitoring and control is the poor data quality and sensor consistency due to the tough and complex circumstances of the process operation. This paper presents a new principal component analysis fault detection approach for the nitrate and nitrite concentration sensor based on Water Resource Recovery Facility measurements, together with the Fisher Discriminant A...