Background Cardiovascular diseases are the leading cause of death worldwide. An important mechanism involved is the disruption in protein homeostasis by overactivation of the classical axis of the renin-angiotensin system. The counterregulatory axis counteracts these effects; however, the MrgD receptor has recently been described, and its effects are unknown. Thus, this study aims to evaluate the impact of MrgD deficiency on c...

Halophilic microorganisms are central to biotechnology, bioremediation, and astrobiology because they persist under extreme and polyextreme conditions analogous to extraterrestrial environments. Although metagenomics has transformed the study of halophilic biodiversity, available datasets remain fragmented and unevenly documented. To assess how halophilic metagenomic research reflects the global exploration of hypersaline envi...

This study evaluates the potential impacts of hypothetical nuclear accidents at the Almirante Álvaro Alberto Nuclear Power Plant (CNAAA), located in Angra dos Reis (RJ), in the southeastern region of Brazil, through the integration of advanced atmospheric modeling and Geographic Information Systems (GIS). The study area is characterized by complex environmental features, including mountainous terrain, remnants of the Atlantic...

Glutaric acidemia type 1 (GA I) is caused by deficient activity of glutaryl-CoA dehydrogenase, leading to predominant accumulation of glutaric acid (GA) in the brain. GA I patients present progressive neurological deterioration whose pathophysiology is only partially elucidated. We investigated whether intracerebral GA administration, alone or combined with quinolinic acid (QA), a pro-inflammatory intermediate of the kynurenin...

The untapped microbial diversity of the Amazon region represents a strategic frontier for biotechnological applications. This study screened, identified, and evaluated the potential of yeasts isolated from Amazonian environments to bioconvert sugarcane bagasse hydrolysate into ethanol and xylitol. The lignocellulosic hydrolysate was obtained by thermochemical treatment using H 2 SO 4 (0.78% v/v) at 121 °C for 68 min, with a 20...

Background and aims Sustainable citrus production requires nitrogen (N) management strategies that account for soil–plant nutrient interactions, particularly those affecting calcium (Ca) nutrition. In fertigated citrus orchards, strategies differing in NO₃⁻:NH₄⁺ balance and associated Ca supply affect soil chemical properties, plant nutritional status, fruit yield, and NUE. This study evaluated the effects of contrasting ferti...

This study evaluated the effects of increasing inclusion levels of biological silage produced from tambaqui ( Colossoma macropomum ) by-products (BST) in diets of commercial hens at different ages. A completely randomized design in a 2 × 5 factorial arrangement was adopted, comprising two hen ages (23 and 83 weeks) and five BST inclusion levels (0, 1, 2, 3, and 4%), with four replicates of six birds per treatment. Moderate BST...

Heat stress is a growing challenge for cattle production in tropical environments, particularly for Bos taurus breeds, which are generally less heat‑tolerant. Several locally adapted breeds have evolved morphological and physiological traits that combine characteristics of both Bos taurus and Bos indicus subspecies. We evaluated seasonal changes in semen quality and their association with environmental conditions and external...

Termite alate flights represent the main means of population dispersal and may be influenced by multiple factors, such as climatic dynamics and the intrinsic structure of colonies. This study aimed to record termite flights within the urban matrix and evaluate their relationship with different levels of urbanization. Sampling was conducted over three consecutive years (2019 to 2022) at 57 locations in João Pessoa (PB), northea...

The Tocantins–Araguaia Basin, one of the largest and most ecologically significant watersheds in South America, harbors high biodiversity and provides essential ecosystem services. This study offers a comprehensive assessment of the scientific literature on the Tocantins–Araguaia River Basin using automated content analysis. We compared publication trends and research topics across major Brazilian river basins and applied Stru...

The specific ecological characteristics of the species mean that most capture methods are selective, giving rise to sampling bias. Despite their selectivity, mist nets are the most widespread method for bat capture. This research aimed to test the efficiency of ultrathin mist nets compared to regular nets used to capture bats. Sampling was conducted monthly from December 2022 to August 2023 at Pico do Jabre, Serra do Teixeira...