The Intranasal route provides an effective pathway for insulin delivery to the brain compared to oral/subcutaneous routes as it provides direct access to the brain, bypassing the restrictive blood-brain barrier (BBB), while minimizing systemic exposure. The present study investigated the potential of a thermoresponsive polymer, PNPHO, as a nanocarrier for brain-targeted insulin delivery through the intranasal route, with the a...

The health and integrity of freshwater ecosystems are significantly affected by anthropogenic pressures. Understanding the ecological conditions of freshwater ecosystems is crucial for effective conservation and management strategies. In this study, we developed a new multimetric index, the Karun Fish-Macroinvertebrate Index (KFMI), that incorporates data on fish and macroinvertebrate assemblages to assess the ecological condi...