Introduction This study evaluated the nutritional, physiological, immunological and histomorphometric effects of different solid-state fermented fish silages in juvenile European sea bass ( Dicentrarchus labrax ) fed a plant-protein-based diet for 70 days. Methods Fish byproduct silage made from the redbelly tilapia ( Coptodon zillii ) were tested as the control group T1, four solid-state fermented silage; with acidic acid fis...

Di-n-butyl phthalate (DBP) is a conventional plasticizer known to induce hepatotoxicity and nephrotoxicity through oxidative stress and apoptosis. In contrast, curcumin, a polyphenolic compound from Curcuma longa , has significant antioxidant and anti-apoptotic activity; however, its therapeutic efficiency is limited due to poor absorption and low bioavailability. Nanoliposomes can significantly enhance the stability and absor...

The gut microbiome plays a crucial role in fish health, yet its diversity across life stages remains poorly understood, especially in juveniles. This study provides a comprehensive assessment of the gut microbiome in wild adult and juvenile Mugil cephalus from the Mediterranean estuary, Ashtum El-Gamil, Egypt, by integrating prokaryotic 16S and eukaryotic 18S rRNA gene metabarcoding with functional gene prediction. Gut bacteri...

Brown seaweed has gained special attention in aquaculture nutrition studies due to its functional bioactive compounds, such as polysaccharides. This study evaluated the functional potential of the brown seaweed, Ascophyllum nodosum , as a natural immunostimulant and growth promoter in Nile tilapia. A 74-day feeding experiment was conducted using 540 fingerlings (initial body weight 18.4 ± 0.2 g), randomly allocated to six diet...

Triple-negative breast cancer (TNBC) is a highly aggressive and heterogeneous subtype with limited treatment options and poor clinical outcomes. Tinengotinib (TT-00420), a spectrum-selective multi-kinase inhibitor, has emerged as a promising candidate for targeting multiple dysregulated pathways in TNBC. This study employed an integrative in silico strategy—combining network pharmacology, molecular docking, molecular dynamics...