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NARA Subscribed2
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Springer Nature2
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GeroScience2
Publication Year
20202
Alida A. Postma results 2 · Newest (Page 1/1, per page 25)
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Imaging the role of blood–brain barrier disruption in normal cognitive ageingNARA Subscribed
GeroScience · 2020 · Vol. 42 · Issue 6 · Springer
Inge C. M. Verheggen; Joost J. A. de Jong; Martin P. J. van Boxtel; Alida A. Postma; Jacobus F. A. Jansen; Frans R. J. Verhey; Walter H. Backes
To investigate whether blood–brain barrier (BBB) disruption is a potential mechanism of usual age-related cognitive decline, we conducted dynamic contrast–enhanced (DCE) MRI to measure BBB leakage in a healthy sample, and investigated the association with longitudinal cognitive decline. In a sample of neurologically and cognitively healthy, older individuals, BBB leakage rate in the white and grey matter and hippocampus was me...
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Increase in blood–brain barrier leakage in healthy, older adultsNARA Subscribed
GeroScience · 2020 · Vol. 42 · Issue 4 · Springer
Inge C. M. Verheggen; Joost J. A. de Jong; Martin P. J. van Boxtel; Ed H. B. M. Gronenschild; Walter M. Palm; Alida A. Postma; Jacobus F. A. Jansen; Frans R. J. Verhey; Walter H. Backes
Blood–brain barrier (BBB) breakdown can disrupt nutrient supply and waste removal, which affects neuronal functioning. Currently, dynamic contrast-enhanced (DCE) MRI is the preferred in-vivo method to quantify BBB leakage. Dedicated DCE MRI studies in normal aging individuals are lacking, which could hamper value estimation and interpretation of leakage rate in pathological conditions. Therefore, we applied DCE MRI to investig...
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