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Remotely Sensed Fire Heterogeneity and Biomass Recovery Predicts Empirical Biodiversity ResponsesNARA Subscribed
Aim To compare field‐based evidence of plant and animal responses to fire with remotely sensed signals of fire heterogeneity and post‐fire biomass recovery. Location South‐eastern Australia; New South Wales. Time Period 2019–2022. Major Taxa Studied A total of 982 species of plants and animals, in eight taxonomic groups: amphibians, birds, fish, insects, mammals, molluscs, plants and reptiles. Methods We collated 545,223 plant...
Conserved and Unique Protein Expression Patterns Across Reproductive Stage Transitions in Social Hymenopteran QueensNARA Subscribed
Hymenopteran queens are collectively highly fecund, often long‐lived individuals that undergo dramatic physiological changes after they mate and establish a nest. However, the degree to which these changes are conserved among species with different life histories is not well‐defined. We conducted a comparative proteomic study investigating differences between reproductive stages (virgin, mated and established queens) of Apis m...
Mechanistic safety assessment via multi-omic characterisation of systemic pathway perturbations following in vivo MAT2A inhibitionNARA Subscribed
The tumour suppressor p16/CDKN2A and the metabolic gene, methyl-thio-adenosine phosphorylase (MTAP), are frequently co-deleted in some of the most aggressive and currently untreatable cancers. Cells with MTAP deletion are vulnerable to inhibition of the metabolic enzyme, methionine-adenosyl transferase 2A (MAT2A), and the protein arginine methyl transferase (PRMT5). This synthetic lethality has paved the way for the rapid deve...
Common, low-frequency, rare, and ultra-rare coding variants contribute to COVID-19 severityNARA Subscribed
The combined impact of common and rare exonic variants in COVID-19 host genetics is currently insufficiently understood. Here, common and rare variants from whole-exome sequencing data of about 4000 SARS-CoV-2-positive individuals were used to define an interpretable machine-learning model for predicting COVID-19 severity. First, variants were converted into separate sets of Boolean features, depending on the absence or the pr...
Genomics, transcriptomics and proteomics: enabling insights into social evolution and disease challenges for managed and wild beesNARA Subscribed
Globally, there are over 20 000 bee species ( Hymenoptera: Apoidea: Anthophila ) with a host of biologically fascinating characteristics. Although they have long been studied as models for social evolution, recent challenges to bee health (mainly diseases and pesticides) have gathered the attention of both public and research communities. Genome sequences of twelve bee species are now complete or under progress, facilitating t...
Wind disturbance profoundly shapes temperate forests but few studies have evaluated patterns and mechanisms of long‐term forest dynamics following major windthrows. In 1990, we initiated a large hurricane simulation experiment in a 0.8‐ha manipulation (pulldown) and 0.6‐ha control area of a maturing Quercus rubra – Acer rubrum forest in New England. We toppled 276 trees in the pulldown, using a winch and cable, in the northwes...
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