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Main conclusion Trait development for commercial heirloom tomatoes can be advanced by optimization of tissue culture and transformation via Agrobacterium and CRISPR/Cas9 mutagenesis. Abstract Genetic improvement using new genome editing approaches relies on the efficient delivery of the CRISPR/Cas system in the vegetable crop tomato. Previous protocols for tomato transformation have primarily focused on a handful of cultivars...
Dryland ecosystems cover 41% of Earth's land surfaces, account for 44% of cultivated lands and 60% of food sources, and make large contributions to the global water and carbon cycles. However, these ecosystems are experiencing unprecedented extremes including heatwaves, floods, and droughts as well as hotter temperatures and often declining water resource availability. These ecosystems are some of the most challenging to monit...
Alzheimer’s disease (AD) disproportionately affects women and carriers of the apolipoprotein E ε4 allele (APOE4), yet little is known about how sex and APOE interact to influence white matter (WM) integrity during disease progression. We integrated diffusion MRI and matched blood transcriptomic data to investigate these interactions and their underlying biological mechanisms. WM microstructure was quantified using diffusion te...
The Toxicology Investigators Consortium 2024 Annual ReportNARA Subscribed
Despite extensive research on life-extending interventions, rigorous statistical techniques to determine their impact on compression of morbidity (CoM) are rarely used. We present a case example of an analytical method for examining the effect of life-extending dietary interventions on CoM by comparing the rates of decline in vitality and survival toward the end of life. Using data from previous experimental studies in mice, w...
Deficits in cerebral blood flow (CBF) and cerebrovascular reactivity (CVR) may indicate vulnerability to vascular dysfunction and cognitive impairment. Prior findings on age-related change in CVR are mixed, and no studies to date have investigated age group differences in spontaneous CVR (sCVR) at rest. The present study compared whole brain and regional sCVR at rest between 24 healthy younger adults (ages 18–34) and 163 cogni...
Cerebral hypoperfusion, brain structural integrity, and cognitive impairment in older APOE4 carriersNARA Subscribed
Cerebral blood flow (CBF) deficits, cognitive decline, and brain structural changes have been reported in older adults with and without apolipoprotein E-e4 ( APOE4 )-related risk for dementia. However, it remains unclear whether brain structural changes mediate the effects of hypoperfusion on cognitive impairment in APOE4 carriers and non-carriers. We studied 166 (60–89 years) APOE4 carriers (ε3/ε4 or ε4/ε4) and APOE3 homozygo...
The Toxicology Investigators Consortium 2023 Annual ReportNARA Subscribed
Broadening inclusivity at seaOA Marine
Ocean sciences in the U.S. remains a field with one of the lowest rates of diversity, having disproportionately low representation from marginalized groups, including Black, Asian, LatinX, Indigenous, and other people of color; LGBTQIA+ individuals; disabled persons; women; those with neurological differences; and those from low-income groups. With equity and inclusion in mind, recent efforts have been made to increase the num...
Artificial intelligence in paleontologyNARA Subscribed