The objective of this study was to perform genomic, phylogenomic, and phenotypic characterization of bacterial isolates from a captive Cacatua alba to investigate their antimicrobial resistance profiles, virulence-associated genes, and genomic relationships with publicly available strains. Bacterial isolates obtained from the lungs and encephalon were identified as Escherichia coli (AV037), Enterobacter hormaechei (AV038), and...

Foodborne illnesses, particularly those caused by Salmonella spp., represent a major global health concern, with S. typhimurium being a significant contributor to outbreaks. The persistence of S. typhimurium in food production environments and its resistance to conventional disinfectants highlight the need for alternative antimicrobial solutions. Essential oils (EOs) from Eucalyptus globulus (EGEO) and Cymbopogon flexuosus (CF...

Sporotrichosis is a globally distributed subcutaneous mycosis caused by fungi belonging to the Sporothrix genus. The limitations of current treatment options for sporotrichosis have driven an urgent search for new antifungal drugs. Diphenyl diselenide (PhSe)₂, a stable organoselenium, has promising activity against Sporothrix spp. Since chemical modifications in molecules can enhance their antifungal properties, this study aim...

The widespread use of aromatic herbicides such as 2,4-dichlorophenoxyacetic acid (2,4-D) has led to persistent environmental contamination, requiring efficient and sustainable biodegradation strategies. In this study, we isolated and characterized a novel actinobacterial strain, Streptomyces sp. SCPE-10, from contaminated coastal soil, capable of using 2,4-D as its sole carbon source. Phenotypic assays revealed robust growth o...

Angiostrongylus vasorum is a metastrongylid nematode that parasitizes the pulmonary arteries and right heart of canids, being the etiological agent of canine angiostrongylosis, a disease of growing veterinary concern due to its expanding geographic distribution and the involvement of domestic and wild hosts. In Brazil, the parasite has been reported mainly in domestic dogs and some wild canids, and its occurrence in mustelids...

This study evaluated early weaning (EW) versus conventional weaning (CW) and dam parity (DP) effects on carcass traits, meat quality, and the muscle metabolome of male offspring exposed in utero during the intervention. A randomized complete-block design with a 2 × 2 factorial arrangement compared weaning strategies (WS: EW at 150 d lactation/80 d gestation vs. CW at 240 d lactation/170 d gestation) and dam parities (DP: multi...

Organotellurium (OTe) compounds have pharmacological properties, including leishmanicidal, antimalarial, and antifungal activities. Herein, we assessed cytotoxicity effects of OTe RF07 in a panel of tumor cell lines, as well as its oxidative, toxicity, and hemolytic actions. The toxicity was evaluated on Allium cepa and Artemia salina larvae. Cell viability was also assessed by resazurin in murine cells (Sarcoma 180), human ce...

Methylmalonic acidemia is an inherited neurometabolic disorder characterized by accumulation of methylmalonic acid (MMA) in different tissues, particularly in the brain. As a result, patients frequently exhibit progressive neurological deterioration, accompanied by episodes of acute encephalopathy following metabolic decompensation. Astrocytes are glial cells that maintain the central nervous system homeostasis and may be impo...

The Southwestern Atlantic Ocean (SWAO) is an important feeding and developmental area for loggerhead turtle ( Caretta caretta ). However, long-term patterns of resource use across life stages and sexes remain poorly understood for the species in this region. Here, we used stable isotope analysis (SIA) of sequential layers of carapace scutes to investigate resource use of loggerhead turtles in the SWAO across life stages and se...

Background Benign prostatic hyperplasia (BPH) is a highly prevalent condition among aging men and a major cause of lower urinary tract symptoms (LUTS). Although α1-adrenoceptor blockers and 5-alpha-reductase inhibitors remain the cornerstone of treatment, their long-term use is frequently limited by adverse effects and suboptimal symptom control. Growing experimental and clinical evidence suggests that chronic prostatic inflam...

To highlight the significance of unique subterranean ecosystems, the concept of Hotspots of Subterranean Biodiversity (HSB) was introduced to designate caves or cave systems with exceptionally high richness of cave-restricted species, which often require urgent conservation measures. The Cuchillo Curá cave system, the largest in Patagonia (Argentina) and the richest in cave-restricted fauna, exemplifies such a hotspot, althoug...