Drug tolerance (DT) is a critical attribute of anti-drug antibody (ADA) assays for assessing clinical immunogenicity. We present a unique situation where a previously approved commercial product, atezolizumab, required re-assessment of the assay DT to meet an increased drug exposure demand arising from a new route of administration (subcutaneous) and align with updated health authority (HA) regulations. Rather than redevelop t...

Summary In the open ocean genetically diverse clades of the unicellular cyanobacteria P rochlorococcus are biogeographically structured along environmental gradients, yet little is known about their in situ activity. To address this gap, here we use the numerically dominant P rochlorococcus clade e HL ‐ II (e MIT 9312) as a model organism to develop and apply a method to examine their in situ activity using r RNA content and c...