Amanda Rodrigues results 244
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Chronic kidney disease is an increasing global public health concern, and the Developmental Origins of Health and Disease (DOHaD) concept proposes that adverse conditions during critical developmental windows predispose offspring to chronic disorders later in life. Maternal protein restriction (MPR), a well-established experimental model reflecting food insecurity, has been shown to impair nephrogenesis and promote long-term r...
Campylobacter jejuni strains isolated in Brazil have important virulence related genes and survive to different stress conditionsNARA Subscribed
Campylobacter jejuni has been reported as the leading bacterial pathogen that causes foodborne gastroenteritis in humans in many countries. This study aimed to assess the survival of 46 C. jejuni strains isolated from food (14), humans (18), and animals (14) in Brazil from 1996–2016 under different stress conditions, evaluate their invasion and survival capacity in Caco-2 cells and U-937 macrophages and determine virulence usi...
Multidrug-resistant (MDR) Klebsiella pneumoniae , particularly high-risk clones such as sequence type (ST) 147, have been increasingly reported worldwide. However, data on their occurrence in reproductive disorders of companion animals remain limited. This study describes, for the first time, an extended-spectrum β-lactamase (ESBL)-producing K. pneumoniae ST147 isolated from a canine paraprostatic abscess. The isolate (UNISA-D...
Mechanisms of dyspnoea and exercise intolerance in smokers with preserved ratio impaired spirometryNARA Subscribed
Purpose Smokers with preserved ratio impaired spirometry (PRISm) present reduced forced expiratory volume in the first second (FEV₁ < 80% predicted) but preserved FEV 1 /forced vital capacity (FVC) ≥ 0.7. Although they do not meet diagnostic criteria for chronic obstructive pulmonary disease (COPD), they often report respiratory symptoms and exercise intolerance. We aimed to compare sensory and physiological responses to exerc...
Central toxic effects of an antitumoral bufadienolide: In silico targets and in vivo findingsNARA Subscribed
Marinobufagin (MBG), a cardiotonic steroid from Rhinella toads, exhibits potent antitumor activity. However, their involvement in the mammalian neurotoxicity remains unclear. Therefore, this study evaluated the systemic (neuro)toxicological action of MBG to understand its central effects, particularly those associated with seizure-inducing activity. Initially, physicochemical, pharmacokinetic, and drug-likeness profiles and mo...
Kaolin-based particle film mitigates high light stress in native tree seedlings through anatomical and growth adjustmentsNARA Subscribed
Deforestation and environmental degradation increase the need for effective strategies to improve seedling establishment in ecological restoration programs, particularly under high irradiance conditions. Although processed kaolin particle film (PKPF) has been widely used to mitigate abiotic stress in agricultural crops, its potential application to native forest species during restoration remains poorly understood. This study...
Glycine is a fundamental neuroactive amino acid that serves dual roles in the central nervous system: acting as a primary inhibitory neurotransmitter via strychnine-sensitive glycine receptors and as an essential co-agonist at the N-methyl-D-aspartate (NMDA) receptor. This dual functionality is important for maintaining the excitation–inhibition balance, synaptic plasticity, and network stability. The spatial and temporal avai...
Bovine mastitis is one of the major challenges in dairy production, causing significant economic losses and emphasizing the need for alternatives to the indiscriminate use of antibiotics. Palo Santo ( Bursera graveolens ) essential oil (BEO) presents recognized biological properties that can be enhanced through nanoengineered delivery systems. This study aimed to chemically characterize the BEO of B. graveolens , develop a nan...