Amanda Ross results 28
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Interpretable deep learning reveals spatiotemporal MRI features of brain aging that align with neurodegenerationNARA Subscribed
Cortical thinning and atrophy are hallmarks of brain aging that have been characterized using magnetic resonance imaging (MRI). Brain aging involves many neuroanatomic features whose effects on brain structure remain unexplored. To address this challenge, we trained interpretable deep neural networks (DNNs) to estimate brain age (BA) from T 1 -weighted ( T 1 w) MRI. By identifying MRI features unapparent to humans, DNNs can fi...
Alzheimer’s disease (AD) disproportionately affects women and carriers of the apolipoprotein E ε4 allele (APOE4), yet little is known about how sex and APOE interact to influence white matter (WM) integrity during disease progression. We integrated diffusion MRI and matched blood transcriptomic data to investigate these interactions and their underlying biological mechanisms. WM microstructure was quantified using diffusion te...
The key mechanisms associated with the survival of Gulf toadfish, Opsanus beta , when in severe hypoxiaNARA Subscribed
Florida's shallow seagrass beds experience daily diurnal fluctuations in environmental oxygen, leading to hypoxic episodes (PO 2 −1 , ~6 kPa) that have increased in frequency and intensity in recent decades. The native Gulf toadfish ( Opsanus beta ) have been shown to employ a suite of adaptive cardiovascular, ventilatory and metabolic adjustments to survive moderate hypoxia, but little is known of the mechanisms used to survi...
Predicting the progression of MCI and Alzheimer’s disease on structural brain integrity and other features with machine learningNARA Subscribed
Machine learning (ML) on structural MRI data shows high potential for classifying Alzheimer’s disease (AD) progression, but the specific contribution of brain regions, demographics, and proteinopathy remains unclear. Using Alzheimer’s Disease Neuroimaging Initiative (ADNI) data, we applied an extreme gradient-boosting algorithm and SHAP (SHapley Additive exPlanations) values to classify cognitively normal (CN) older adults, th...
Early‐life environmental conditions can provide a source of individual variation in life‐history strategies and senescence patterns. Conditions experienced in early life can be quantified by measuring telomere length, which can act as a biomarker of survival probability in some species. Here, we investigate whether seasonal changes, weather conditions and group size are associated with early‐life and/or early‐adulthood telomer...
Measuring and modelling microclimatic air temperature in a historically degraded tropical forestNARA Subscribed
Climate change is predicted to cause widespread disruptions to global biodiversity. Most climate models are at the macroscale, operating at a ~ 1 km resolution and predicting future temperatures at 1.5–2 m above ground level, making them unable to predict microclimates at the scale that many organisms experience temperature. We studied the effects of forest structure and vertical position on microclimatic air temperature withi...
Overwintering and migration behaviour of post‐spawned Atlantic salmon Salmo salar in a large hydropower‐regulated river and reservoirNARA Subscribed
Tracking 47 post‐spawned adult Atlantic salmon Salmo salar L. in a hydropower‐regulated river through autumn, winter and spring revealed that winter survival was 56% and 75% in two study years, respectively, with higher mortality of males than females (50% vs . 33% and 100% vs . 13%, respectively). Some kelts ( n = 7) displayed nondirected movements that were interpreted as a reconditioning period for an average of 9–17 days p...
Tropicalization is a term used to describe the transformation of temperate ecosystems by poleward‐moving tropical organisms in response to warming temperatures. In North America, decreases in the frequency and intensity of extreme winter cold events are expected to allow the poleward range expansion of many cold‐sensitive tropical organisms, sometimes at the expense of temperate organisms. Although ecologists have long noted t...
Sleeping tree selection and related behaviours of a family group and a solitary female siamang ( Symphalangus syndactylus ) were investigated over a 5-month period in northern Sumatra, Indonesia. We performed all day follows, sleeping tree surveys and forest plot enumerations in the field. We tested whether: (1) physical characteristics of sleeping trees and the surrounding trees, together with siamang behaviours, supported se...
Classifying Chimpanzee (Pan troglodytes) Landscapes Across Large-Scale Environmental Gradients in AfricaNARA Subscribed
Primates are sometimes categorized in terms of their habitat. Although such categorization can be oversimplistic, there are scientific benefits from the clarity and consistency that habitat categorization can bring. Chimpanzees ( Pan troglodytes ) inhabit various environments, but researchers often refer to “forest” or “savanna” chimpanzees. Despite the wide use of this forest–savanna distinction, clear definitions of these la...
Assessing multiple predator, diurnal and search area effects on predatory impacts by ephemeral wetland specialist copepodsNARA Subscribed
Predator–prey interaction strengths can be highly context-dependent. In particular, multiple predator effects (MPEs), variations in predator sex and physical habitat characteristics may affect prey consumption rates and thus the persistence of lower trophic groups. Ephemeral wetlands are transient ecosystems in which predatory copepods can be numerically dominant. We examine the interaction strengths of a specialist copepod Pa...
Sex demographics alter the effect of habitat structure on predation by a temporary pond specialistNARA Subscribed
Habitat structure can profoundly influence interaction strengths between predators and prey. Spatio-temporal habitat structure in temporary wetland ecosystems is particularly variable because of fluctuations in water levels and vegetation colonisation dynamics. Demographic characteristics within animal populations may also alter the influence of habitat structure on biotic interactions, but have remained untested. Here, we inv...
Trophic structure of mesopelagic fishes in the Gulf of Mexico revealed by gut content and stable isotope analysesNARA Subscribed
Mesopelagic fishes represent an important component of the marine food web due to their global distributions, high abundances and ability to transport organic material throughout a large part of the water column. This study combined stable isotope ( SIA s) and gut content analyses ( GCA s) to characterize the trophic structure of mesopelagic fishes in the North‐Central Gulf of Mexico. Additionally, this study examined whether...
Genome-wide association study of endometrial cancer in E2C2NARA Subscribed