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Interpretable deep learning reveals spatiotemporal MRI features of brain aging that align with neurodegenerationNARA Subscribed
Cortical thinning and atrophy are hallmarks of brain aging that have been characterized using magnetic resonance imaging (MRI). Brain aging involves many neuroanatomic features whose effects on brain structure remain unexplored. To address this challenge, we trained interpretable deep neural networks (DNNs) to estimate brain age (BA) from T 1 -weighted ( T 1 w) MRI. By identifying MRI features unapparent to humans, DNNs can fi...
Malaria, a febrile disease caused by the Plasmodium parasites and transmitted by mosquitoes, is a leading cause of mortality in children under 5 in endemic countries. The widespread deployment of insecticide‐treated bed nets (ITNs) has significantly reduced malaria transmission, but rising levels of insecticide resistance threaten to halt the progress. Monitoring insecticide resistance is vital for effective vector control, pa...
Alzheimer’s disease (AD) disproportionately affects women and carriers of the apolipoprotein E ε4 allele (APOE4), yet little is known about how sex and APOE interact to influence white matter (WM) integrity during disease progression. We integrated diffusion MRI and matched blood transcriptomic data to investigate these interactions and their underlying biological mechanisms. WM microstructure was quantified using diffusion te...
Marine megafauna species are affected by a wide range of anthropogenic threats. To evaluate the risk of such threats, species’ vulnerability to each threat must first be determined. We build on the existing threats classification scheme and ranking system of the International Union for Conservation of Nature (IUCN) Red List of Threatened Species by assessing the vulnerability of 256 marine megafauna species to 23 at‐sea threat...
The Toxicology Investigators Consortium 2024 Annual ReportNARA Subscribed
Linking Climate and Demography to Predict Population Dynamics and Persistence Under Global ChangeNARA Subscribed
Predicting the effects of climate change on plant and animal populations is an urgent challenge for understanding the fate of biodiversity under global change. At the surface, quantifying how climate drives the vital rates that underlie population dynamics appears simple, yet many decisions are required to connect climate to demographic data. Competing approaches have emerged in the literature with little consensus around best...
Low genetic variation and strong genetic structure across a range of geographical scales in European smelt ( Osmerus eperlanus L.)NARA Subscribed
Populations of anadromous European smelt ( Osmerus eperlanus L.) are declining across its range with mitigation efforts for this ecologically important species hindered by a lack of demographic information. Here, mitochondrial DNA (mtDNA) and microsatellite analyses were used to describe historical and recurrent demographics for the species across a large part of its range. mtDNA revealed a shallow phylogeographic structure in...
The Greatest Extinction Event in 66 Million Years? Contextualising Anthropogenic ExtinctionsNARA Subscribed
Biological communities are changing rapidly in response to human activities, with the high rate of vertebrate species extinction leading many to propose that we are in the midst of a sixth mass extinction event. Five past mass extinction events have commonly been identified across the Phanerozoic, with the last occurring at the end of the Cretaceous, 66 million years ago (Ma). However, life on Earth has always changed and evol...
The Cost of Antivenom: A Cost Minimization Study using the North American Snakebite RegistryNARA Subscribed
Envenomation is a global health issue, with over 9,000 encounters managed in the United States yearly. The introduction of immunoglobulin fragment antivenom has reduced the risk of hypersensitivity. This study compares treatment costs of crotaline envenomation using the Fab and F(ab’) 2 antivenoms as reported to the North American Snakebite Registry (NASBR), a nationwide surveillance tool. Methods This was a retrospective anal...