Activation of brown adipose tissue (BAT) or subcutaneous adipose tissue (iWAT in mice) is a strategy to regulate metabolic homeostasis. The NAD + -dependent deacetylase Sirtuin 1 (SIRT1) plays an essential role in energy metabolism and inflammation and is a promising target to tackle obesity and associated comorbidities. We have previously reported the beneficial effect of moderate SIRT1 overexpression in protecting mice again...