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Regulatory Roles of Long Non-Coding RNAs in Methotrexate Pharmacology: Mechanistic and Translational InsightsNARA Subscribed
Background Methotrexate (MTX) remains a cornerstone therapy in autoimmune diseases and oncology; however, substantial interindividual variability in efficacy and toxicity persists. While variability in MTX pharmacokinetics (PK) and pharmacodynamics (PD) has been linked to transporters, folate-cycle enzymes, and intracellular polyglutamate accumulation, the contribution of long non-coding RNAs (lncRNAs) as regulatory modifiers...
Under the current global biodiversity crisis, there is a need for automated and noninvasive monitoring techniques that can gather large amounts of data cost‐effectively at various ecological scales, from local to large spatial scales. These data can then be analyzed to inform stakeholders and decision‐makers. One such technique is passive acoustic monitoring, which is commonly coupled with automatic identification of animal sp...
Comparison of Methods for Analyzing Environmental Mixtures Effects on Survival OutcomesNARA Subscribed
Purpose of Review Estimating the effect of environmental mixtures on survival outcomes is common in epidemiological studies, yet the applicability and performance of advanced mixture modeling methods in this context remains underexplored. In this review, we identify available methods for this context and evaluate their performance via simulations. Recent Findings We compared five methods – Cox Proportional Hazards (with/withou...
Nutrients on the move: Investigating large scale fatty acid exports from European ponds via emerging insectsNARA Subscribed
Permanent ponds are key landscape units that supply various ecosystem services. Notably, the export of aquatic subsidies to land via emerging insects may significantly influence terrestrial food webs. Polyunsaturated fatty acids (PUFA), which enhance consumer fitness, are among the essential exported components. The patterns and drivers of dietary exports from ponds via insects remain poorly known, particularly at continental...
Evaluating the Impact of High Source Variability and Extreme Contributing Sources on Sediment Fingerprinting ModelsNARA Subscribed
Sediment fingerprinting is a powerful tool used in drainage basin analysis to identify and quantify sediment sources, crucial for effective water management strategies. However, methodological debates persist regarding the influence of tracer type, tracer selection, and source dominance on fingerprinting model accuracy. This study introduces a novel linear variability propagation analysis (LVP method) to address and quantify p...