Background Cardiovascular diseases are the leading cause of death worldwide. An important mechanism involved is the disruption in protein homeostasis by overactivation of the classical axis of the renin-angiotensin system. The counterregulatory axis counteracts these effects; however, the MrgD receptor has recently been described, and its effects are unknown. Thus, this study aims to evaluate the impact of MrgD deficiency on c...

The anesthetic management of female dogs with mammary neoplasia, usually classified as ASA II and undergoing invasive procedures such as mastectomy and ovariohysterectomy, requires effective sedation and anesthetic stability due to the increased anesthetic risk associated with advanced age and underlying disease. In this context, this study aimed to evaluate the sedative effects and reduction in anesthetic requirements of a fu...

Increasing life expectancy has been accompanied by a higher prevalence of age-associated conditions, underscoring the need to better understand biological mechanisms of aging and to identify accessible biomarkers. Extracellular vesicles (EVs) are lipid-bilayer vesicles that mediate intercellular communication by transporting proteins, lipids, and regulatory RNAs, including microRNAs (miRNAs). Here, we investigated whether the...

Corn is a globally important crop; however, pest infestations during storage represent a major challenge. The maize weevil, Sitophilus zeamais (Coleoptera: Curculionidae), is a primary pest of stored maize, commonly controlled through phosphine fumigation. Nevertheless, extensive reliance on this insecticide has led to the emergence of resistant populations. Thus, the objective of this study was to evaluate the contact and fum...

Morningglory species ( Ipomoea spp.) are important weeds in Brazilian agriculture, particularly in non-burning sugarcane farming system. The fungus Cercospora aff. canescens has been selected as potential mycoherbicide; however, inoculum production is considered a challenge. The purpose of this study was to define and optimize culture conditions for biomass and spore yield of Cercospora aff. canescens CMAA 1444 in submerged fe...

Prosopis juliflora was introduced to the Brazilian semi-arid region as a forage and firewood plant and spontaneously dispersed to valley areas and now forms almost pure stands in more than 500,000 ha of the region. Since eradication is not being considered, studies on the advantages and disadvantages are necessary. One of the potential advantages is the capability of symbiotically fixing atmospheric N 2 . We determined P. juli...

The genus Amblyomma koch, 1844 contains approximately 138 species, which are mainly distributed in the Afrotropical, Oriental, Neotropical and Australasian zoogeographic regions. This is an important group of arthropod vectors responsible for transmitting a wide range of etiological agents that cause infections and diseases in humans and animals, and is therefore of great interest to public and veterinary health.This study des...

This study aimed to evaluate the effect of topical application of a mouth gel formulation containing iron tetracarboxyphthalocyanine (FeTcPc) during non-surgical periodontal treatment. Forty-seven individuals with periodontitis underwent a standard periodontal treatment (scaling and root planing), followed by adjuvant therapy according to the = groups: Vehicle Group ( n = 15), receiving local application of the FeTcPc gel vehi...

Aim We investigate the distribution of dispersal modes — endozoochory (via animal ingestion), synzoochory (via animal seed accumulation) and anemochory (via wind)—and seed mass of woody plants across Brazilian ecosystems, testing whether their relative abundance in local plant communities could be predicted by climate, edaphic factors and dispersal agents (e.g., the main vectors moving seeds). We expected climate to be the mai...

Background At the end of 2019, severe acute respiratory syndrome (SARS) caused by the novel coronavirus SARS-CoV-2 emerged in China, representing one of the most significant global health threats of the twenty-first century. This study aimed to evaluate the phenotypic and cellular activation of epithelial cells in tracheal aspirate samples from patients with severe COVID-19. Methods A total of 48 samples were collected from 28...

Given the ongoing climate change, information on species distribution is becoming increasingly necessary, particularly for species with restricted distribution ranges, such as endemic ones. We used ecological niche modeling to evaluate the distribution of 28 species of vascular epiphytes endemic to the Amazonia under current and future scenarios. We analyzed the climatic factors influencing current and future environmental sui...

Assessment frameworks do not capture the complexity of the social–ecological dynamics of small-scale fisheries (SSF), which support millions of livelihoods yet face persistent sustainability challenges. Reciprocal feedbacks between fish populations and fishers that are central to sustainability remain insufficiently integrated into assessment approaches because conventional fisheries management emphasizes population dynamics,...

Cetaceans face multiple threats, and pollution has become a major concern for their conservation worldwide. This study assessed metal(loid) concentrations in the tissues of two odontocete species with coastal and oceanic habits, namely Guiana dolphin ( Sotalia guianensis ; n = 11) and the false killer whale ( Pseudorca crassidens ; n = 8), respectively, stranded along the northeastern Brazilian equatorial margin. Silver (Ag),...