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Springer Nature1
Journal
Molecular Neurobiology1
Publication Year
20241
Anand Deva results 1 · Newest (Page 1/1, per page 25)
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C9orf72-Associated Dipeptide Repeat Expansions Perturb ER-Golgi Vesicular Trafficking, Inducing Golgi Fragmentation and ER Stress, in ALS/FTDNARA Subscribed
Molecular Neurobiology · 2024 · Vol. 61 · Issue 12 · Springer
Jessica Sultana; Audrey M. G. Ragagnin; Sonam Parakh; Sayanthooran Saravanabavan; Kai Ying Soo; Marta Vidal; Cyril Jones Jagaraj; Kunjie Ding; Sharlynn Wu; Sina Shadfar; Emily K. Don; Anand Deva; Garth Nicholson; Dominic B. Rowe; Ian Blair; Shu Yang; Julie D. Atkin
Hexanucleotide repeat expansions (HREs) in the chromosome 9 open reading frame 72 ( C9orf72 ) gene are the most frequent genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Both are debilitating neurodegenerative conditions affecting either motor neurons (ALS) in the brain and spinal cord or neurons in the frontal and/or temporal cortical lobes (FTD). HREs undergo repeat-associated non-ATG (...
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