Andrea Colombo results 39
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Design of 3D-printed hydroxyapatite intervertebral fusion cages in a patient specific frameworkNARA Subscribed
Fusion surgery involves replacing degenerated intervertebral discs with artificial implants, usually composed of titanium alloys or PEEK, requiring bone grafting to assist tissue growth. This study aims to evaluate numerically 3D-printed porous ceramic implants as a bioactive alternative. Clinical computed tomographies of an adult patient were used to reconstruct the geometry and to assign mechanical properties to L1 and L2 ve...
Space capacity-based metric to rank in orbit collision riskNARA Subscribed
Influence of the climate extreme events recorded in 2022 and 2023 on carbon and nitrogen forms in alpine tundraNARA Subscribed
Alpine tundra ecosystems are highly sensitive to climate change, particularly due to their dependence on the duration and timing of snow cover. This study investigated the effects of the climate extreme years 2022 and 2023 on carbon (C) and nitrogen (N) forms in two alpine tundra communities: snowbed (SB) and Carex curvula (CC), located at high elevation in the North-West (NW) Italian Alps. During these years, both sites exper...
The italian national genomic strategy: current status, challenges, and future perspectives in clinical practice and public healthNARA Subscribed
This article presents the outcomes of a national initiative aimed at developing a technical document to support the future Italian National Genomic Strategy, carried out from 2021 to 2024 through the collaboration of 14 research institutions. The project was designed to align with major European genomic initiatives, particularly the “1 + Million Genomes” (1 + MG) Declaration and its supporting programs, including Beyond 1 Mill...
Detailed knowledge of dietary preferences in wild species are important both for understanding evolutionary processes as well as for their conservation. By means of DNA metabarcoding analysis of faecal samples, we investigated the diet of Alpine ibex ( Capra ibex ), a mountain ungulate characterised by strong sexual dimorphism and segregation, and analysed differences between male and female diet. Despite a low level of select...
Environmental impact of object breakup in medium-Earth orbitNARA Subscribed
Are natural deep eutectic solvents always a sustainable option? A bioassay-based studyNARA Subscribed
The traditional use of organic solvents in various branches of industry is being rethought as these compounds very often display high volatility, toxicity and lipophilicity (related to the ability to interact with biological membranes). More recently, developments in the field of Green Chemistry are focusing on the design of more sustainable and cost-effective solvent alternatives like Ionic Liquids (ILs), bio-based solvents a...
Common, low-frequency, rare, and ultra-rare coding variants contribute to COVID-19 severityNARA Subscribed
The combined impact of common and rare exonic variants in COVID-19 host genetics is currently insufficiently understood. Here, common and rare variants from whole-exome sequencing data of about 4000 SARS-CoV-2-positive individuals were used to define an interpretable machine-learning model for predicting COVID-19 severity. First, variants were converted into separate sets of Boolean features, depending on the absence or the pr...