Frontotemporal dementia (FTD) is a neurodegenerative disease characterized by significant clinical and genetic heterogeneity, with approximately 40% of cases linked to hereditary genetic mutations, including MAPT , GRN , and C9ORF72 . Recently, microRNAs (miRNAs) have emerged as key regulators of cellular processes related to neurodegeneration and as potential biomarkers for FTD. However, their relevance in presymptomatic stag...

The brown alga Fucus virsoides, an endangered species endemic to the Adriatic Sea, is subjected to increasingly changing ecological conditions in the intertidal zone, potentially driving its extinction. In this study, temperature fluctuations at one of the last remaining F. virsoides sites in the Istrian region (northern Adriatic) during a 1-year period were analysed and found to be only partially associated with water level c...

The European endemic barbels represent important bioindicators of river quality and are nowadays threatened by changing environmental conditions and hybridization with the invasive alien Barbus barbus . It is therefore fundamental to investigate interactions among species and adaptability to climate changes in protected areas of Northern Apennines. An investigation was carried out considering 248 barbel samples that were analy...

Marine biodiversity monitoring in the Mediterranean’s increasingly threatened ecosystems is crucial for effective ecosystem conservation and management. Here, we leveraged the Mediterranean International Trawl Survey program (MEDITS) to implement eDNA sampling through the recently tested ‘metaprobe’ procedure and characterize fish assemblages in three separate areas off the Italian coasts: Northern Adriatic Sea (NoAS), Liguria...

A well-validated storm surge numerical model is crucial, offering precise coastal hazard information and serving as a basis for extensive databases and advanced data-driven algorithms. However, selecting the best model setup based solely on common error indicators like the root-mean-square error (RMSE) or Pearson correlation does not always yield optimal results. To illustrate this, we conducted 34-year high-resolution simulat...