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Effects of verification stage intensity and duration on $$\dot{V}O_{{2\max }}$$ determinationNARA Subscribed
Purpose Verification stages are recommended for maximal oxygen consumption (V̇O ₂max ) determination, but there is currently no standardization of verification stage design. We sought to determine if the length of recovery and the initial intensity of subsequent exercise influence the effectiveness of verification stages during testing for V̇O ₂max . Methods Twenty-seven participants (20 males, 7 females) completed four graded...
Coverage matters: identifying and mitigating sampling frame issues in recreational fishing surveysNARA Subscribed
Surveys play an integral part in monitoring and maintaining sustainable recreational fisheries. For any probabilistic survey, the selection of a sampling frame (e.g., list of individuals or fishers) is an important decision because it influences the ability to provide unbiased estimates of recreational catch and effort. Undercoverage occurs when units of the target population (i.e., the population of interest) are missing from...
Voxel-wise insights into early Alzheimer’s disease pathology progression: the association with APOE and memory declineNARA Subscribed
Longitudinal investigation of the Apolipoprotein E (APOE) genotype’s impact on Alzheimer’s disease (AD) biomarker progression, focusing on amyloid beta (Aβ) accumulation and gray matter (GM) atrophy, integrating cognitive decline and baseline levels. Longitudinal florbetapir-PET and T1-weighted MRI data from 100 cognitively normal (CN) and mild cognitive impaired (MCI) participants both with considerable global Aβ accumulation...
Remotely Sensed Fire Heterogeneity and Biomass Recovery Predicts Empirical Biodiversity ResponsesNARA Subscribed
Aim To compare field‐based evidence of plant and animal responses to fire with remotely sensed signals of fire heterogeneity and post‐fire biomass recovery. Location South‐eastern Australia; New South Wales. Time Period 2019–2022. Major Taxa Studied A total of 982 species of plants and animals, in eight taxonomic groups: amphibians, birds, fish, insects, mammals, molluscs, plants and reptiles. Methods We collated 545,223 plant...
The Coastal Ocean Environment Summer School In Nigeria and Ghana (COESSING; https://coessing.org) has been run for one week every year since 2015. The school, an endorsed project of the United Nations Decade of Ocean Science for Sustainable Development (2021–2030), has provided a platform for approximately 1,000 scientists from Africa, the United States, and Europe to exchange scientific knowledge, to network, to learn, and to...
Complementary value of molecular, phenotypic, and functional aging biomarkers in dementia predictionNARA Subscribed
DNA methylation age (MA), brain age (BA), and frailty index (FI) are putative aging biomarkers linked to dementia risk. We investigated their relationship and combined potential for prediction of cognitive impairment and future dementia risk using the ADNI database. Of several MA algorithms, DunedinPACE and GrimAge2, associated with memory, were combined in a composite MA alongside BA and a data-driven FI in predictive analyse...
Defining an ageing-related pathology, disease or syndrome: International Consensus StatementNARA Subscribed
Around the world, individuals are living longer, but an increased average lifespan does not always equate to an increased health span. With advancing age, the increased prevalence of ageing-related diseases can have a significant impact on health status, functional capacity and quality of life. It is therefore vital to develop comprehensive classification and staging systems for ageing-related pathologies, diseases and syndrom...
Mechanistic safety assessment via multi-omic characterisation of systemic pathway perturbations following in vivo MAT2A inhibitionNARA Subscribed
The tumour suppressor p16/CDKN2A and the metabolic gene, methyl-thio-adenosine phosphorylase (MTAP), are frequently co-deleted in some of the most aggressive and currently untreatable cancers. Cells with MTAP deletion are vulnerable to inhibition of the metabolic enzyme, methionine-adenosyl transferase 2A (MAT2A), and the protein arginine methyl transferase (PRMT5). This synthetic lethality has paved the way for the rapid deve...
Deliberately introduced dung beetles in A ustralia: 12 years of occurrence and abundance records from 2001 to 2022NARA Subscribed
Since 1968, the Australian Dung Beetle Project has carried out field releases of 43 deliberately introduced dung beetle species for the biological control of livestock dung and dung‐breeding pests. Of these, 23 species are known to have become established. For most of these species, sufficient time has elapsed for population expansion to fill the extent of their potential geographic range through both natural and human‐assiste...