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Geospatial heterogeneity of hotspots for incidence and late-stage diagnosis of breast, colorectal, and lung cancerNARA Subscribed
Purpose Cancer control relies on the identification of populations at risk (hotspots) of new or late-stage cancer diagnoses. However, the extent to which hotspots differ between cancer sites or between outcome measures has been poorly characterized. We sought to determine the geospatial heterogeneity of hotspots of breast, colorectal, and lung cancer incidence and late-stage diagnoses. Methods We identified adult patients diag...
Ectomycorrhizal fungal diversity may be influenced by arbuscular mycorrhizal trees in mixed temperate forestsNARA Subscribed
Mycorrhizal fungi are critical plant mutualists that influence nutrient cycling, yet we have an incomplete understanding of factors driving their diversity and function. While it’s presumed that diverse host plant communities support diverse mycorrhizal fungal communities, abiotic factors and non-host plants may also be important. We investigated whether ectomycorrhizal fungal (ECMF) communities in soils and roots varied among...
Interpretable deep learning reveals spatiotemporal MRI features of brain aging that align with neurodegenerationNARA Subscribed
Cortical thinning and atrophy are hallmarks of brain aging that have been characterized using magnetic resonance imaging (MRI). Brain aging involves many neuroanatomic features whose effects on brain structure remain unexplored. To address this challenge, we trained interpretable deep neural networks (DNNs) to estimate brain age (BA) from T 1 -weighted ( T 1 w) MRI. By identifying MRI features unapparent to humans, DNNs can fi...
Environmental Variability Shapes Life‐History Trade‐Offs Within and Between Populations of a Long‐Lived SeabirdNARA Subscribed
Individuals face a trade‐off between allocating resources to reproduction or self‐maintenance, yet the drivers of the existence and strength of such trade‐off have been hard to determine. Environmental conditions are thought to play a crucial role, as long‐lived species are predicted to favour more precautionary life‐history strategies in variable environments. However, empirical evidence remains limited. Using long‐term monit...
Diagnosing scaling bottlenecks in 10 community conservation initiatives in southern and eastern AfricaNARA Subscribed
Scaling area‐based conservation, including initiatives led or comanaged by Indigenous Peoples and local communities, is a flagship goal of the Kunming‐Montreal Global Biodiversity Framework. Conservationists often aspire to scale initiatives, but this is rarely achieved in practice. Identifying and addressing factors that limit initiative adoption (i.e., bottlenecks) could improve scaling strategies. We used insightsfrom 84 ex...
Alzheimer’s disease (AD) disproportionately affects women and carriers of the apolipoprotein E ε4 allele (APOE4), yet little is known about how sex and APOE interact to influence white matter (WM) integrity during disease progression. We integrated diffusion MRI and matched blood transcriptomic data to investigate these interactions and their underlying biological mechanisms. WM microstructure was quantified using diffusion te...
The Toxicology Investigators Consortium 2024 Annual ReportNARA Subscribed
Aim Predicting the potential distribution of an invasive species is critical for informing decisions around surveillance, containment and eradication. Mechanistic species distribution models directly describe how aspects of the environment affect organismal fitness through space and time. These models also provide insight into population dynamics, such as rates of population growth and spread. Here, we develop a temperature‐de...
Marimo for monitoring and filtering of aquatic environmentsNARA Subscribed
Aegagropila linnaei (commonly known as “Marimo”) forms dense spheres of intertwined algae filaments capable of capturing and retaining a wide range of particles and microorganisms (up to 2 mm in length) from freshwater environments. This study explores the potential of Marimo as a sustainable tool for environmental monitoring and water filtration. We present a novel, non-destructive method for extracting entrapped materials (i...
Background and aims Previously, triple super phosphate (TSP) application to one soil type was unexpectedly found to cause with soil drying an initiation of linear decrease in maize transpiration rate at an unusually high soil water content. The resulting overall slower soil water extraction resulted in crop drought resilience. A key issue is whether the response occurs with drying of other soils. The objective of this study wa...