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Springer Nature1
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The AAPS Journal1
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20231
Angela Dimitrova results 1 · Newest (Page 1/1, per page 25)
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Leveraging Prior Healthy Participant Pharmacokinetic Data to Evaluate the Impact of Renal and Hepatic Impairment on Ritlecitinib PharmacokineticsNARA Subscribed
The AAPS Journal · 2023 · Vol. 25 · Issue 3 · Springer
Vivek Purohit; Yeamin Huh; Jessica Wojciechowski; Anna Plotka; Stephanie Salts; Jeremias Antinew; Angela Dimitrova; Timothy Nicholas
Ritlecitinib is a selective, covalent, irreversible inhibitor of Janus kinase 3 (JAK3) and the tyrosine kinase expressed in hepatocellular carcinoma (TEC) family kinases. Pharmacokinetics and safety of ritlecitinib in participants with hepatic (Study 1) or renal (Study 2) impairment were to be characterized from two phase I studies. Due to a study pause caused by the COVID-19 pandemic, the study 2 healthy participant (HP) coho...
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