Cerebral cavernous malformations (CCMs) are clusters of thin-walled enlarged blood vessels in the central nervous system that are prone to recurrent hemorrhage and can occur in both sporadic and familial forms. The familial form results from loss-of-function variants in the CCM1 , CCM2 , or CCM3 gene. Despite a better understanding of CCM pathogenesis in recent years, it is still unclear why CCM3 mutations often lead to a more...

Since the last decades, previous long-term Wadden Sea studies revealed significant changes in the abundance, biomass and spatial distribution of characteristic macrofauna communities in response to environmental changes and anthropogenic stressors. In this study, we performed statistical community analysis for the East-Frisian Wadden Sea (EFWS, southern North Sea) on two reference datasets across a period with severe climatic...