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The Toxicology Investigators Consortium 2024 Annual ReportNARA Subscribed
Motivation and retrospective appraisal of psychedelic study participation: a qualitative study in healthy volunteersNARA Subscribed
Rationale Little is known about motives of healthy volunteers to participate in psychedelic trials and how they appraise their study experience retrospectively. Objectives This paper explored reasons why healthy people register for psychedelic trials, factors that they considered to contribute to either positive or negative study experiences, and under which circumstances they would seek a psychedelic experience again. Methods...
Climate‐driven shifts in herbivores, temperature, and nutrient runoff threaten coastal ecosystem resilience. However, ecological resilience, particularly for foundation species, remains poorly understood due to the scarcity of field experiments conducted across appropriate spatial and temporal scales that investigate multiple stressors. This study evaluates the resilience of a widespread tropical marine plant (turtlegrass) to...
The deubiquitinating enzyme CYLD negatively regulates NF-κB signaling by removing activating ubiquitin chains from several members of the NF-κB pathway. Thereby, CYLD is critical for the maintenance and differentiation of various immune cells. Despite the importance of the NF-κB pathway in microglia regulation, the role of CYLD in microglia has not been investigated so far. In this study, we investigated whether CYLD in microg...
The Toxicology Investigators Consortium 2023 Annual ReportNARA Subscribed
Tidal asymmetry in estuaries and other tidally dominated coastal systems is commonly evaluated to assess system states or their development. Based on different methods, local states are classified as either flood or ebb dominant. An increasing number of descriptors for deriving tidal asymmetry in recent years calls for a comparison and discussion of their sensitivity on input data and its quality. We compared tidal asymmetry f...
Purification and concentration of infectious koi herpesvirus using steric exclusion chromatographyNARA Subscribed
Koi herpesvirus (KHV) is the causative agent of a koi herpesvirus disease (KHVD) inducing high mortality rates in common carp and koi ( Cyprinus carpio ). No widespread effective vaccination strategy has been implemented yet, which is partly due to side effects of the immunized fish. In this study, we present an evaluation of the purification of infectious KHV from host cell protein and DNA, using the steric exclusion chromato...
Patterns of small involuntary fixation saccades (SIFSs) in different neurodegenerative diseases: the role of noiseNARA Subscribed
During the attempt to steadily fixate at a single spot, sequences of small involuntary fixation saccades (SIFSs, known also as microsaccades οr intrusions) occur which form spatio-temporal patterns such as square wave jerks (SWJs), a pattern characterised by alternating centrifugal and centripetal movements of similar magnitude. In many neurodegenerative disorders, SIFSs exhibit elevated amplitudes and frequencies. Elevated SI...
Cholangiocarcinoma (CCA) are the second most common primary liver tumors and carry a dismal prognosis. Chemosaturation with percutaneous hepatic perfusion (PHP) is a palliative, intra-arterial therapeutic approach that provides a high dose chemotherapy of the liver with reduced systemic exposure. Aim of this retrospective, monocentric study was to analyze PHP as a palliative treatment for unresectable CCA. Toxicity, adverse ev...
Freshwater grazers are suitable organisms to investigate the fate of environmental pollutants, such as weathered multi-walled carbon nanotubes (wMWCNTs). One key process is the uptake of ingested materials into digestive or absorptive cells. To address this, we investigated the localization of wMWCNTs in the intestinal tracts of the mud snail Lymnaea stagnalis ( L. stagnalis ) and the mayfly Rhithrogena semicolorata ( R. semic...
The Caatinga is an exclusively Brazilian biome, and is the largest and most biodiverse Seasonal Tropical Dry Forest in the world. Despite that, the mammalian fauna, especially small mammals, is the least studied of all Brazilian biomes. In order to fill gaps and provide detailed information on small mammals (Didelphimorphia, Rodentia) in the Caatinga biome, we compiled reliable records focusing on richness, composition and som...
Flashback phenomena after administration of LSD and psilocybin in controlled studies with healthy participantsNARA Subscribed
Background LSD and psilocybin are increasingly used in phase I trials and evaluated as therapeutic agents for mental disorders. The phenomenon of reoccurring drug-like experiences after the acute substance effects have worn off was described for both substances and especially attributed to LSD. According to the DSM-V, the persisting and distressing manifestation of these experiences is called hallucinogen-persisting perception...
Climate variability and aridity modulate the role of leaf shelters for arthropods: A global experimentNARA Subscribed
Current climate change is disrupting biotic interactions and eroding biodiversity worldwide. However, species sensitive to aridity, high temperatures, and climate variability might find shelter in microclimatic refuges, such as leaf rolls built by arthropods. To explore how the importance of leaf shelters for terrestrial arthropods changes with latitude, elevation, and climate, we conducted a distributed experiment comparing a...
Subtle structures with not‐so‐subtle functions: A data set of arthropod constructs and their host plantsNARA Subscribed
The construction of shelters on plants by arthropods might influence other organisms via changes in colonization, community richness, species composition, and functionality. Arthropods, including beetles, caterpillars, sawflies, spiders, and wasps often interact with host plants via the construction of shelters, building a variety of structures such as leaf ties, tents, rolls, and bags; leaf and stem galls, and hollowed out st...
Impacts of Personalized Sensor Feedback Regarding Exposure to Environmental StressorsNARA Subscribed
Feedback on personal exposure to air pollution, noise or extreme temperatures through wearable sensors or sensors installed at home or in the workplace can offer information that might motivate behaviours to mitigate exposure. As personal measurement devices are becoming increasingly accessible, it is important to evaluate the effects of such sensors on human perception and behaviour. We conducted a systematic literature resea...
Genetic mutations to the Lamin A/C gene ( LMNA ) can cause heart disease, but the mechanisms making cardiac tissues uniquely vulnerable to the mutations remain largely unknown. Further, patients with LMNA mutations have highly variable presentation of heart disease progression and type. In vitro patient-specific experiments could provide a powerful platform for studying this phenomenon, but the use of induced pluripotent stem...