Capillary malformation (CM) is a congenital vascular anomaly that affects the skin, mucosa, eye, and brain. A major obstacle to mechanistic and drug screening studies for CM has been the lack of preclinical models. In this study, we established vascular organoids (VOs) generated through the self-assembly of vascular lineages of endothelial cells and smooth muscle cells differentiated from CM-induced pluripotent stem cells (iPS...

The free‐air CO 2 enrichment (FACE) site at the Birmingham Institute of Forest Research (BIFoR) is situated in a long‐established mature, temperate oak‐dominated forest. Over the past 8 years, these tree species have been exposed to elevated CO 2 (eCO 2 target: 150 ppm above ambient). The observed eCO 2 fertilization effect is significant in the mature oak trees, with sustained increases in photosynthesis and stem dry matter p...

The Caenorhabditis Intervention Testing Program (CITP) is an NIH-funded research consortium of investigators who conduct analyses at three independent sites to identify chemical interventions that reproducibly promote health and lifespan in a robust manner. The founding principle of the CITP is that compounds with positive effects across a genetically diverse panel of Caenorhabditis species and strains are likely engaging cons...

Voriconazole has been associated with cutaneous squamous cell carcinoma (cSCC) in transplant patients but less is known about the risk in less severely immunosuppressed patients. Our aim was to estimate the incidence of cSCC after voriconazole exposure in patients with chronic pulmonary aspergillosis on a background of chronic lung disease. The notes of patients seen at a tertiary referral centre from 2009 to 2019 with chronic...

Forage fish occupy a central position in marine food‐webs worldwide by mediating the transfer of energy and organic matter from lower to higher trophic levels. The lesser sandeel ( Ammodytes marinus ) is one of the ecologically and economically most important forage fish species in the North‐east Atlantic, acting as a key prey for predatory fish and sea birds, as well as supporting a large commercial fishery. In this case stud...

Timing of reproduction greatly influences offspring success and resulting population production. Explaining and predicting species' dynamics necessitates disentangling the intrinsic (genotypic) and extrinsic (climatic) factors controlling reproductive timing. Here we explore temporal and spatial changes in spawning time for 21 populations of Atlantic cod ( Gadus morhua ) across the species' range (40° to 80° N). We estimate sp...