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Springer Nature1
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Molecular Neurobiology1
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20241
Anne Puls results 1 · Newest (Page 1/1, per page 25)
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Neuronal Stem Cells from Late-Onset Alzheimer Patients Show Altered Regulation of Sirtuin 1 Depending on Apolipoprotein E Indicating Disturbed Stem Cell PlasticityNARA Subscribed
Molecular Neurobiology · 2024 · Vol. 61 · Issue 3 · Springer
Matthias Jung; Juliane-Susanne Jung; Jenny Pfeifer; Carla Hartmann; Toni Ehrhardt; Chaudhry Luqman Abid; Jenny Kintzel; Anne Puls; Anne Navarrete Santos; Thomas Hollemann; Dagmar Riemann; Dan Rujescu
Late-onset Alzheimer’s disease (AD) is a complex multifactorial disease. The greatest known risk factor for late-onset AD is the E4 allele of the apolipoprotein E (APOE), while increasing age is the greatest known non-genetic risk factor. The cell type-specific functions of neural stem cells (NSCs), in particular their stem cell plasticity, remain poorly explored in the context of AD pathology. Here, we describe a new model th...
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