The latest hypothesis regarding the source of enhanced neural activation from resistance training is the reticulospinal rather than the corticospinal tract, based on invasive animal and emerging human data. The present study employed a six-week isometric resistance training intervention in a randomized controlled design to address this knowledge gap. Thirty-nine healthy, untrained males (age ~23 y, sustained contraction group...

Sustainable groundwater management is key to building resilience to hydrological extremes but remains challenging in data-scarce transboundary river basins. In this study, a transboundary, collaborative, physically based groundwater modelling approach has been developed for the Limpopo River Basin (LRB), which is highly vulnerable to floods and droughts. Monitoring data and model results consistently suggest that prolonged wet...

Purpose We examined temporal trends in NSAID use among patients referred for evaluation of suspected coronary artery disease (CAD). Methods We conducted a drug utilisation study using population-based healthcare data from Western Denmark, covering 3.3 million inhabitants. Three cohorts were categorised based on first-time diagnostic procedure for CAD assessment: coronary computed tomography angiography (CCTA; 2008–2022, n = 91...

Arctic freshwater biodiversity is rapidly changing due to climate warming, resource extraction, infrastructure development, and landscape transformation. To improve understanding, predict future responses, and inform policy formulation, research needs must be clearly identified. Using a horizon scan survey, Arctic freshwater experts from government, international agencies, and Indigenous Peoples identified 77 biodiversity rese...

Diversification of farming systems at plot scale is increasingly seen as an essential option to meet agriculture sustainability challenges and support agroecological transition. Significant progress has been made in recent years on methods for designing diversified cropping systems based on annual crops. However, few methods have been tested for designing diversified cropping systems based on perennial crops, and in particular...

Marine bacteria significantly influence the development and productivity of algal communities. The green seaweed Ulva ( Chlorophyta) relies on bacteria that secrete algal growth and morphogenesis-promoting factors (AGMPF). In a reductionist model system of Ulva compressa (cultivar U. mutabilis ), the diverse microbiome can be substituted by two key bacteria, Roseovarius sp. MS2 and Maribacter sp. MS6, both of which release AGM...

The Asia region harbors exceptional chondrichthyan (shark, ray, and chimaera) diversity but faces intense fishing pressure. The Important Shark and Ray Areas (ISRA) process provides a collaborative, evidence-based framework to identify critical habitats and inform spatial management. We assessed ISRAs across the Bay of Bengal, Southeast Asia, and the Northwest Pacific to characterize their extent, ecological significance, and...

Early‐life telomere length can be an integrated and accessible biomarker of lifetime fitness. Telomere length can result from complex interactions between heritable genetic variation, inherited gametic variation and accumulated environmental effects acting on individuals and parents. Consequently, to understand early‐life telomere length and its fitness consequences, both offspring traits and intergenerational effects resultin...

Chronological age is a common and non-modifiable factor for chronic disease, but does not fully explain age-related changes. Biological clocks have been developed to explore biological aging mechanisms. They could help identify protective factors against accelerated aging and associated diseases. We aim to assess the association between reduced epigenetic or inflammatory aging and ideal cardiovascular health or cardiovascular...

Frontotemporal dementia (FTD) is a neurodegenerative disease characterized by significant clinical and genetic heterogeneity, with approximately 40% of cases linked to hereditary genetic mutations, including MAPT , GRN , and C9ORF72 . Recently, microRNAs (miRNAs) have emerged as key regulators of cellular processes related to neurodegeneration and as potential biomarkers for FTD. However, their relevance in presymptomatic stag...

Metacommunity theory has expanded our understanding of how spatial dynamics and local interactions influence species communities. Different assembly archetypes, reflecting different roles of species differences, habitat differences, and dispersal have been described, but we lack empirical studies specifically in terrestrial habitats testing which archetype is most important. In a replicated design, we experimentally enhanced s...

Infectious pancreatic necrosis virus (IPNV) can cause devastating disease in Atlantic salmon ( Salmon salar ) . IPNV has a broad host range and may threaten other aquaculture species. Understanding interspecies transmission of IPNV is crucial for protecting the aquaculture industry. With the expansion of fish farming (in Norway), it is important to assess whether a pathogen can transmit from one fish species to another and cau...