Diversification of farming systems at plot scale is increasingly seen as an essential option to meet agriculture sustainability challenges and support agroecological transition. Significant progress has been made in recent years on methods for designing diversified cropping systems based on annual crops. However, few methods have been tested for designing diversified cropping systems based on perennial crops, and in particular...

The objective was to apply a population model to describe the time course and variability of serum creatinine (sCr) in (near)term neonates with moderate to severe encephalopathy during and after therapeutic hypothermia (TH). The data consisted of sCr observations up to 10 days of postnatal age in neonates who underwent TH during the first 3 days after birth. Available covariates were birth weight (BWT), gestational age (GA), s...

Participatory approaches to science and decision making, including stakeholder engagement, are increasingly common for managing complex socio-ecological challenges in working landscapes. However, critical questions about stakeholder engagement in this space remain. These include normative, political, and ethical questions concerning who participates, who benefits and loses, what good can be accomplished, and for what, whom, an...

Conservation approaches to social-ecological systems have largely been informed by a framing of preserving nature for its instrumental societal benefits, often ignoring the complex relationship of humans and nature and how climate change might impact these. The Nature Futures Framework (NFF) was developed by the Task Force on scenarios and models of the Intergovernmental Science-Policy Platform on Biodiversity and Ecosystem Se...

Summary Arsenic, a highly cytotoxic and cancerogenic metalloid, is brought into the biosphere through geochemical sources and anthropogenic activities. A global biogeochemical arsenic biotransformation cycle exists in which inorganic arsenic species are transformed into organoarsenicals, which are subsequently mineralized again into inorganic arsenic compounds. Microorganisms contribute to this biotransformation process greatl...

Background and purpose of the study Propylene glycol (PG) is a frequently co-administered solvent in formulations administered to neonates, but reports on its (in)tolerance are limited. We aimed to report on renal, metabolic and hepatic tolerance before, during and following intravenous (iv) PG-paracetamol exposure and compared these data with similar datasets reported in literature on neonates exposed to PG without paracetamo...