Uncertainties in hydrological models arise primarily from the subsurface architecture and hydrological properties of each unit. This paper presents a method to simulate structural uncertainties in large-scale hydrostratigraphic or geological models by generating multiple realizations constrained by quantified uncertainties. The simulation is based on the geology-driven modeling (GDM) method. GDM requires quantified uncertainty...

Proteases play a central role in regulating renal pathophysiology and are increasingly evaluated as actionable drug targets. Here, we review the role of proteolytic systems in inflammatory kidney disease. Inflammatory kidney diseases are associated with broad dysregulations of extracellular and intracellular proteolysis. As an example of a proteolytic system, the complement system plays a significant role in glomerular inflamm...