Atmospheric fronts are associated with precipitation and strong diabatic processes. Therefore, detecting fronts objectively from reanalyses is a prerequisite for the long-term study of their weather impacts. For this purpose, several algorithms exist, e.g., based on the thermal front parameter (TFP) or the F diagnostic that combines relative vorticity and horizontal temperature gradient. It is shown that both methods have prob...

Purpose Occupational exposure limits (OEL) for nitrogen oxides (NO, NO 2 ) and diesel exhaust (EC-DPM) were reassessed by the German authorities in 2016/2017. We performed a clinical cross-sectional study among salt and potash underground workers exposed to these substances at relatively high levels to examine possible indicators of acute effects on workers’ health. Methods We measured post- versus pre-shift differences in car...

Purpose Tizanidine, an alpha-adrenergic substance with antinociceptive and antihypertensive effects, is extensively metabolized via cytochrome P450 (CYP) 1A2. Therefore, coadministration with potent CYP1A2 inhibitors, such as ciprofloxacin, is contraindicated. However, both drugs are broadly utilized in various countries. Their concomitant use bears an inherent high risk for clinically significant symptoms, especially in multi...