Purpose of Review Estimating the effect of environmental mixtures on survival outcomes is common in epidemiological studies, yet the applicability and performance of advanced mixture modeling methods in this context remains underexplored. In this review, we identify available methods for this context and evaluate their performance via simulations. Recent Findings We compared five methods – Cox Proportional Hazards (with/withou...

Purpose Liver cancer incidence among American Indians/Alaska Natives has risen over the past 20 years. Peripheral blood DNA methylation may be associated with liver cancer and could be used as a biomarker for cancer risk. We evaluated the association of blood DNA methylation with risk of liver cancer. Methods We conducted a prospective cohort study in 2324 American Indians, between age 45 and 75 years, from Arizona, Oklahoma,...