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Glypican-4 (GPC-4), an endothelial cell surface protein, is released into the circulation in the context of ischemia, inflammation, neurohumoral activity, and shear stress. This study aimed to investigate the prognostic value of GPC-4 in chronic heart failure. GPC-4 concentrations were determined in two prospective cohorts: patients with chronic heart failure with reduced ejection fraction (HFrEF), and with transthyretin amylo...
Rationale Delta-9-tetrahydrocannabinol (Δ9-THC) has been reported to evoke psychedelic-like experiences at high doses in some individuals. However, the doses of Δ9-THC that occasion such effects and the phenomenology of these experiences are poorly understood. Objectives This brief report presents preliminary findings from a pilot human laboratory study that directly compared the acute effects of Δ9-THC and psilocybin under se...
Purpose Virtual reality (VR) reduces experimental and clinical pain, but whether these effects extend to naturally occurring muscle pain (NOMP) during exercise remains unclear. This study examined whether immersive nature-based VR attenuates NOMP and improves motor performance during prescribed and self-regulated exercise. Methods Two within-participant crossover studies were conducted involving 12 (Study 1) and 24 (Study 2) h...
Coral bleaching events, in which symbionts are lost from host tissues, have become more frequent and severe because of climate change—specifically, elevated temperatures. How such events impact biogenic volatile organic compound (BVOC) emissions, compounds that can function as metabolic signalling elements, remains underexplored. Here we used gas chromatography coupled with mass spectrometry (GC–MS) to characterise the suite o...
Interpretable deep learning reveals spatiotemporal MRI features of brain aging that align with neurodegenerationNARA Subscribed
Cortical thinning and atrophy are hallmarks of brain aging that have been characterized using magnetic resonance imaging (MRI). Brain aging involves many neuroanatomic features whose effects on brain structure remain unexplored. To address this challenge, we trained interpretable deep neural networks (DNNs) to estimate brain age (BA) from T 1 -weighted ( T 1 w) MRI. By identifying MRI features unapparent to humans, DNNs can fi...
Distributed optical fibre sensing (DOFS) is a technology that enables continuous, real-time measurements of a range of environmental parameters along the length of a fibre optic cable. In this article, we review the recently emerged applications of DOFS techniques in physical oceanography and offer a perspective on the technology's potential for future growth within the field. The introduction of DOFS to physical oceanography...
There is growing interest in deploying insect traps in forest canopies for ecological research, invasive species surveillance, and biodiversity monitoring. However, forest canopies also harbor a diverse and abundant bat community, which may be incidentally trapped and killed by these devices. In this study, we investigated the impact of flight interception traps and multi-funnel traps deployed in oak canopies on incidental bat...
Global wind stilling and the role of sub-monthly variability in explaining deficiencies in atmospheric reanalysesNARA Subscribed
Terrestrial near-surface (10-m) wind speed decreased over the Northern Hemisphere between 1980 and 2010. We revisit this ‘global stilling’ by comparing station-based observations and multiple atmospheric reanalysis products and assessing their ability to capture the past changes in near-surface wind speed. We show, using a station-based wind speed dataset from the Met Office (HadISD3), that global stilling is robust and not an...
Thermal Stress‐Induced Alterations to Oxylipin Signal Receptors in the Cnidarian–Dinoflagellate SymbiosisNARA Subscribed
The continuous exchange of molecular signals between partners in the cnidarian–dinoflagellate symbiosis is fundamental for maintaining a healthy relationship. This homeostasis is affected by rising seawater temperatures resulting from climate change (i.e., coral bleaching), though little is known about how these molecular signals are altered. Here, we investigated the localisation and abundance of four receptors in the sea ane...
Diagnosing scaling bottlenecks in 10 community conservation initiatives in southern and eastern AfricaNARA Subscribed
Scaling area‐based conservation, including initiatives led or comanaged by Indigenous Peoples and local communities, is a flagship goal of the Kunming‐Montreal Global Biodiversity Framework. Conservationists often aspire to scale initiatives, but this is rarely achieved in practice. Identifying and addressing factors that limit initiative adoption (i.e., bottlenecks) could improve scaling strategies. We used insightsfrom 84 ex...
Alzheimer’s disease (AD) disproportionately affects women and carriers of the apolipoprotein E ε4 allele (APOE4), yet little is known about how sex and APOE interact to influence white matter (WM) integrity during disease progression. We integrated diffusion MRI and matched blood transcriptomic data to investigate these interactions and their underlying biological mechanisms. WM microstructure was quantified using diffusion te...